Phytochemical profile and hepatoprotective potentiality of Phyllanthus genus: a review

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Pharmacy and Pharmacology Pub Date : 2024-04-21 DOI:10.1093/jpp/rgae040

H Pratima, Anita Shiraguppi, Priyadarshini Joojagar, Kamal Shah, Sudharani S Cheeraladinni, P Shivakumar Singh, Suresh kumar Mendem, Nagendra Singh Chauhan

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引用次数: 0

Abstract

The Phyllanthus genus is very important plant traded as a raw herbal medicine in India. Commonly known as ‘Bhumyamalaki’ (Phyllanthus species) has been used for the prevention and treatment of jaundice. Phyllanthus is rich in diversity of bioactive compounds such as lignans, alkaloids, terpenoids, flavonoids, and tannins. Among some metabolites such as phyllanthin, hypophyllanthin, 8, 9-epoxy brevifolin, brevifolin, quercetin, gallic acid, elagic acid, and brevifolin carboxylate have been shown to have hepatoprotective and antioxidant activity found in this genus. The basic objective of this review was to overview the hepatoprotective activity based on the other available data from various plants of the Phyllanthus species including Phyllanthus amarus, Phyllanhtus urinaria, Phyllanthus fraternus, Phyllanthus maderaspatenis, Phyllanthus simplex, Phyllanthus emblica, Phyllanthus debillis, Phyllanthus tenellus, Phyllanthus polyphyllus, Phyllanthus reticulates, Phyllanthus indofischerii, Phyllanthus acidus, Phyllanthus niruri, Phyllanthus rheedii, Phyllanthus kozhikodianus, and Phyllanthus longiflorus. These species studied had considerable hepatoprotective potential. The secondary data, each in vitro and in vivo studies confirm the capacity of Phyllanthus species used as a remedy for jaundice or liver disease in addition to having antioxidants. Furthermore, it could be concluded that herbal drugs have the least side effects and are taken into considered safe for human health, they are able to substantially alternative synthetic drugs in the future.

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叶下珠属植物的植物化学成分和保肝潜力：综述

在印度，Phyllanthus 属植物是非常重要的生草药。通常被称为 "Bhumyamalaki"（Phyllanthus 种）的植物被用于预防和治疗黄疸病。Phyllanthus富含多种生物活性化合物，如木质素、生物碱、萜类化合物、黄酮类化合物和单宁酸。在该属植物中发现的一些代谢产物，如叶黄素、次叶黄素、8, 9-环氧蒲公英苷、蒲公英苷、槲皮素、没食子酸、鞣花酸和蒲公英苷羧酸酯等，已被证明具有保肝和抗氧化活性。本综述的基本目的是根据现有的其他数据，概述菲叶属植物的保肝活性，这些植物包括：白菲叶属植物、溲疏菲叶属植物、箭叶菲叶属植物、马德拉斯帕特尼斯菲叶属植物、单叶菲叶属植物、多叶菲叶属植物、箭叶菲叶属植物、箭叶菲叶属植物、箭叶菲叶属植物、箭叶菲叶属植物、箭叶菲叶属植物、箭叶菲叶属植物、箭叶菲叶属植物、箭叶菲叶属植物、箭叶菲叶属植物、箭叶菲叶属植物、箭叶菲叶属植物、Phyllanthus simplex、Phyllanthus emblica、Phyllanthus debillis、Phyllanthus tenellus、Phyllanthus polyphyllus、Phyllanthus reticulates、Phyllanthus indofischerii、Phyllanthus acidus、Phyllanthus niruri、Phyllanthus rheedii、Phyllanthus kozhikodianus 和 Phyllanthus longiflorus。所研究的这些物种具有相当大的保肝潜力。二手数据、每项体外和体内研究都证实，除了具有抗氧化剂外，叶黄素还可用作治疗黄疸或肝病的药物。此外，可以得出的结论是，中草药的副作用最小，对人体健康安全，将来可以大量替代合成药物。

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来源期刊

Journal of Pharmacy and Pharmacology 医学-药学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： JPP keeps pace with new research on how drug action may be optimized by new technologies, and attention is given to understanding and improving drug interactions in the body. At the same time, the journal maintains its established and well-respected core strengths in areas such as pharmaceutics and drug delivery, experimental and clinical pharmacology, biopharmaceutics and drug disposition, and drugs from natural sources. JPP publishes at least one special issue on a topical theme each year.

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