Diego Cruz Vidal, Simon Lee, Stacy P Ardoin, Djhenne Dalmacy, Juan Chaparro, Cristin Blaney, Vilmarie Rodriguez, Amanda Sankar, Shoghik Akoghlanian, Richard Lisciandro, Matthew Washam, Roshini S Abraham, Amy Leber, Meika Eby, Berkeley Bennett, Guliz Erdem
{"title":"Multisystem Inflammatory Syndrome in Children and Cardiac Involvement: A Quaternary Center Experience.","authors":"Diego Cruz Vidal, Simon Lee, Stacy P Ardoin, Djhenne Dalmacy, Juan Chaparro, Cristin Blaney, Vilmarie Rodriguez, Amanda Sankar, Shoghik Akoghlanian, Richard Lisciandro, Matthew Washam, Roshini S Abraham, Amy Leber, Meika Eby, Berkeley Bennett, Guliz Erdem","doi":"10.1097/inf.0000000000004266","DOIUrl":null,"url":null,"abstract":"We prospectively analyzed clinical and laboratory characteristics associated with cardiac involvement and severe presentation in multisystem inflammatory syndrome in children. Of 146 patients, 66 (45.2%) had cardiac dysfunction and 26 (17.8%) had coronary artery abnormalities. Lower serum albumin levels, absolute lymphocyte and platelet counts, and elevated ferritin, fibrinogen, d-dimer and interleukin-6 levels were associated with cardiac dysfunction. Possible treatment complications were identified.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Pediatric Infectious Disease Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/inf.0000000000004266","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
We prospectively analyzed clinical and laboratory characteristics associated with cardiac involvement and severe presentation in multisystem inflammatory syndrome in children. Of 146 patients, 66 (45.2%) had cardiac dysfunction and 26 (17.8%) had coronary artery abnormalities. Lower serum albumin levels, absolute lymphocyte and platelet counts, and elevated ferritin, fibrinogen, d-dimer and interleukin-6 levels were associated with cardiac dysfunction. Possible treatment complications were identified.
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