Multimorbidity and the Etiology of Schizophrenia

IF 5.5 2区医学 Q1 PSYCHIATRY

Current Psychiatry Reports Pub Date : 2024-04-16 DOI:10.1007/s11920-024-01500-9

A. Szoke, B. Pignon, O. Godin, A. Ferchiou, R. Tamouza, M. Leboyer, F. Schürhoff

{"title":"Multimorbidity and the Etiology of Schizophrenia","authors":"A. Szoke, B. Pignon, O. Godin, A. Ferchiou, R. Tamouza, M. Leboyer, F. Schürhoff","doi":"10.1007/s11920-024-01500-9","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of Review</h3><p>A global study of multimorbidity in schizophrenia, especially of the association with physical conditions, might offer much needed etiological insights.</p><h3 data-test=\"abstract-sub-heading\">Recent Findings</h3><p>Our review suggests that life-style factors and medication related to schizophrenia are only part of the explanation of the increase in risk for cardiovascular, metabolic, pulmonary disorders, and some cancers. Positive associations with autoimmune disorders (with the exception of rheumatoid arthritis) and epilepsy are promising avenues of research but to date have not been fully exploited. The same holds for the negative comorbidity seen for rheumatoid arthritis and some cancers (e.g., prostate).</p><h3 data-test=\"abstract-sub-heading\">Summary</h3><p>As a whole, our review suggests that most of the explored conditions have a different prevalence in schizophrenia than in the general population. Several hypotheses emerged from this review such as the role of immune and genetic factors, of sex hormones, and of more general variability factors.</p>","PeriodicalId":11057,"journal":{"name":"Current Psychiatry Reports","volume":null,"pages":null},"PeriodicalIF":5.5000,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Psychiatry Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11920-024-01500-9","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of Review

A global study of multimorbidity in schizophrenia, especially of the association with physical conditions, might offer much needed etiological insights.

Recent Findings

Our review suggests that life-style factors and medication related to schizophrenia are only part of the explanation of the increase in risk for cardiovascular, metabolic, pulmonary disorders, and some cancers. Positive associations with autoimmune disorders (with the exception of rheumatoid arthritis) and epilepsy are promising avenues of research but to date have not been fully exploited. The same holds for the negative comorbidity seen for rheumatoid arthritis and some cancers (e.g., prostate).

Summary

As a whole, our review suggests that most of the explored conditions have a different prevalence in schizophrenia than in the general population. Several hypotheses emerged from this review such as the role of immune and genetic factors, of sex hormones, and of more general variability factors.

Abstract Image

查看原文本刊更多论文

多病共存与精神分裂症病因学

最新研究结果我们的研究表明，与精神分裂症有关的生活方式因素和药物治疗只是导致心血管疾病、代谢性疾病、肺部疾病和某些癌症风险增加的部分原因。与自身免疫性疾病（类风湿性关节炎除外）和癫痫的正相关性是很有希望的研究方向，但迄今为止尚未得到充分利用。总之，我们的综述表明，所探讨的大多数疾病在精神分裂症患者中的发病率与普通人群不同。本综述提出了一些假设，如免疫和遗传因素、性激素以及更普遍的可变因素的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Psychiatry Reports PSYCHIATRY-

CiteScore

11.30

自引率

3.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published research in psychiatry. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by psychiatric disorders. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anxiety, medicopsychiatric disorders, and schizophrenia and other related psychotic disorders. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.