Comparison of Non-ephedrine Constituents from Ephedra Plants Cultivated in Japan

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Chemical & pharmaceutical bulletin Pub Date : 2024-04-17 DOI:10.1248/cpb.c24-00043

Kengo Hayashi, Yuki Miyao, Hina Matsui, Takao Yamaura, Ken Tanaka, Mariko Baba, Hiroaki Hayashi

引用次数: 0

Abstract

Ephedra plants, the main components of which are ephedrine alkaloids, are used as traditional medicines in Eastern Asian countries. In this study, we isolated non-ephedrine constituents from various Ephedra plant species cultivated in Japan. HPLC analysis suggested that kynurenic acid and its derivatives accumulated in a wide range of Ephedra plant species. Furthermore, a large amount of (2R,3S)-O-benzoyl isocitrate has been isolated from E. intermedia. This study suggests that Ephedra plants have diverse non-ephedrine constituents.

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日本种植的麻黄属植物中的非麻黄碱成分比较

麻黄植物的主要成分是麻黄碱，在东亚国家被用作传统药物。在这项研究中，我们从日本栽培的各种麻黄属植物中分离出了非麻黄碱类成分。高效液相色谱分析表明，在多种麻黄属植物中都积累了犬尿苷酸及其衍生物。此外，还从 E. intermedia 中分离出了大量 (2R,3S)-O-苯甲酰基异柠檬酸盐。这项研究表明，麻黄属植物具有多种非麻黄碱成分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical & pharmaceutical bulletin 医学-化学综合

CiteScore

3.20

自引率

5.90%

发文量

132

审稿时长

1.7 months

期刊介绍： The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.