An Insight into Common and Advanced Synthesis Methodologies of Acyl Urea Analogs Targeting the CNS

IF 0.7 4区化学 Q4 CHEMISTRY, ORGANIC

Letters in Organic Chemistry Pub Date : 2024-04-17 DOI:10.2174/0115701786303718240409044341

Preeti Kumari, Rakhi Mishra, Rupa Mazumder, Avijit Mazumder, Ayushi Singh, Gurvinder Singh, Pankaj Kumar Tyagi

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Abstract

: The acyl urea functionality and related analogs are increasingly used in medicinal chemistry and drug design to prove well-defined pharmacological actions and optimal physicochemical properties. This review paper aimed to summarize information related to synthesis methods of acyl urea derivatives, marketed products, and patents to explore their applications in counteracting CNS-related diseases by multiple targeting. Comprehensive data related to acyl urea and related compounds of the last 15 years is collected from various resources to provide enormous information to the readers. The content of the study uniformly includes considerable evidence linked to the common and unique synthesis techniques of acyl urea from starting materials like benzamide, isocyanates, substituted iodoglycals, 2 chloro nicotinic acid, and methyl hydrazines, as well as patents related to the same. This work describes the reactions of several substrates that can be used to manufacture various acyl urea derivatives. An understanding of patents related to acyl urea analogs with specific targets for CNS action may also help researchers working on additional synthesis of acyl urea derivatives with potential CNS action.

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洞察以中枢神经系统为目标的酰基脲类似物的常见和高级合成方法

:酰基脲官能团及相关类似物越来越多地用于药物化学和药物设计，以证明其明确的药理作用和最佳的理化性质。本综述论文旨在总结与酰基脲衍生物的合成方法、上市产品和专利相关的信息，探讨它们在通过多靶点对抗中枢神经系统相关疾病方面的应用。本文从各种资源中收集了近 15 年来与酰基脲及相关化合物有关的综合数据，为读者提供了大量信息。研究内容统一包括与酰基脲从苯甲酰胺、异氰酸酯、取代碘甘氨酸、2-氯烟酸和甲基肼等起始原料的常见和独特合成技术相关的大量证据，以及与之相关的专利。本著作介绍了可用于制造各种酰基脲衍生物的几种底物的反应。了解与具有特定中枢神经系统作用靶点的酰基脲类似物相关的专利，也有助于研究人员进一步合成具有潜在中枢神经系统作用的酰基脲衍生物。

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来源期刊

Letters in Organic Chemistry 化学-有机化学

CiteScore

1.30

自引率

12.50%

发文量

135

审稿时长

7 months

期刊介绍： Aims & Scope Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts. The journal is an essential reading for all organic chemists belonging to both academia and industry.