Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

IF 5.6 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

mAbs Pub Date : 2024-04-18 DOI:10.1080/19420862.2024.2339337

Eva Schlein, Ken G. Andersson, Tiffany Dallas, Stina Syvänen, Dag Sehlin

引用次数: 0

Abstract

Recent development of amyloid-β (Aβ)-targeted immunotherapies for Alzheimer’s disease (AD) have highlighted the need for accurate diagnostic methods. Antibody-based positron emission tomography (PE...

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减少新生儿Fc受体结合可提高TfR递送的双特异性淀粉样蛋白-β抗体的清除率和脑血比

最近，针对阿尔茨海默病（AD）的淀粉样蛋白-β（Aβ）靶向免疫疗法的发展突显了对精确诊断方法的需求。基于抗体的正电子发射断层扫描（PE...

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

mAbs 工程技术-仪器仪表

CiteScore

10.70

自引率

11.30%

发文量

审稿时长

6-12 weeks

期刊介绍： mAbs is a multi-disciplinary journal dedicated to the art and science of antibody research and development. The journal has a strong scientific and medical focus, but also strives to serve a broader readership. The articles are thus of interest to scientists, clinical researchers, and physicians, as well as the wider mAb community, including our readers involved in technology transfer, legal issues, investment, strategic planning and the regulation of therapeutics.