Multifunctional and Sprayable 2D MoS2/Silk Sericin Bio-Nanocomposite Dressings with Enhanced Photothermal Effect for Infected Wound Healing

IF 17.2 1区工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Advanced Fiber Materials Pub Date : 2024-04-15 DOI:10.1007/s42765-024-00407-7

Libin Qiu, Lian Duan, Hongyu Lin, Min Wang, Huaping Liang, Guilong Peng, Xiao Yang, Yang Si, Shixiong Yi

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Abstract

Developing novel antibacterial dressing protecting skin injuries from infection is essential for wound healing. In this study, sericin, a bio-waste produced during the degumming of silk cocoons, is utilized to exfoliate MoS₂ layers and improve the dispersity and stability of MoS₂ nanosheets (MoS₂-NSs). Moreover, owing to its ability to promote oxygen permeability and cell growth and its good biocompatibility, MoS₂-NS/Sericin maintains its photothermal property under an 808 nm light source for a strong antibacterial activity as well as improves the fibroblast migration, which accelerates wound healing. Furthermore, the in vitro experiments indicates that MoS₂-NS/Sericin can also scavenge reactive oxygen species (ROS) at an inflammatory stage of wound healing and transform classical activated macrophages (M1-type) into alternatively activated macrophages (M2-type), which is beneficial for wound recovery. Based on these results observed in vitro, full-thickness skin wound experiments are conducted on rats, and the corresponding results show that MoS₂/Sericin under 808 nm irradiation exhibits the best performance in promoting wound healing. Overall, MoS₂-NS/Sericin exhibits a high potential for bacteria-infected wound healing.

Graphical Abstract

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具有增强光热效应的多功能可喷涂二维 MoS2/丝胶生物纳米复合敷料促进感染伤口愈合

开发新型抗菌敷料保护皮肤损伤免受感染对伤口愈合至关重要。在这项研究中，丝胶（一种在蚕茧脱胶过程中产生的生物废料）被用来剥离 MoS2 层，提高 MoS2 纳米片（MoS2-NSs）的分散性和稳定性。此外，由于 MoS2-NS/Sericin 具有促进氧气渗透和细胞生长的能力以及良好的生物相容性，因此在 808 纳米光源下仍能保持其光热特性，具有很强的抗菌活性，并能改善成纤维细胞迁移，加速伤口愈合。此外，体外实验表明，在伤口愈合的炎症阶段，MoS2-NS/丝胶还能清除活性氧（ROS），并将经典活化巨噬细胞（M1 型）转化为替代活化巨噬细胞（M2 型），有利于伤口恢复。根据体外观察到的这些结果，对大鼠进行了全厚皮肤伤口实验，相应的结果表明，在 808 纳米照射下，MoS2/丝裂霉素在促进伤口愈合方面表现最佳。总之，MoS2-NS/丝胶在细菌感染伤口愈合方面具有很高的潜力。

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来源期刊

Advanced Fiber Materials Multiple-

CiteScore

18.70

自引率

11.20%

发文量

109

期刊介绍： Advanced Fiber Materials is a hybrid, peer-reviewed, international and interdisciplinary research journal which aims to publish the most important papers in fibers and fiber-related devices as well as their applications.Indexed by SCIE, EI, Scopus et al. Publishing on fiber or fiber-related materials, technology, engineering and application.