Neuronal TLR9 signalling crucial for memory formation

IF 67.7 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2024-04-17 DOI:10.1038/s41577-024-01034-4

Alexandra Flemming

引用次数: 0

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神经元 TLR9 信号对记忆形成至关重要

记忆由海马神经元的微电路编码。这些细胞在学习过程中会发生能量密集型分子适应性变化，从而导致短暂的 DNA 损伤。Jovasevic 等人的研究表明，小鼠的情境恐惧条件诱导会在海马 CA1 兴奋性神经元中形成双链 DNA（dsDNA）断裂和炎症基因标志。这些细胞还会上调TLR9，TLR9能与内溶酶体中的dsDNA片段结合，促进DNA损伤修复。海马神经元特异性敲除 Tlr9 会导致这些细胞的遗传不稳定性，并损害情境记忆的形成。用TLR9拮抗剂治疗小鼠也能观察到类似的结果，但细胞膜dsDNA感应的进化 "较早 "cGAS-STING介导途径的抑制剂却不能抑制TLR9。鉴于DNA损伤与神经退行性病变的关系，作者建议，维持神经元中TLR9信号完整性的策略可能具有预防神经认知缺陷的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.

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