Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina.

IF 4.2 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

World Journal of Diabetes Pub Date : 2024-04-09 DOI:10.4239/wjd.v15.i3.519

Jian Tan, Ang Xiao, Lin Yang, Yu-Lin Tao, Yi Shao, Qiong Zhou

引用次数: 0

Abstract

Diabetic retinopathy (DR) is a major ocular complication of diabetes mellitus, leading to visual impairment. Retinal pigment epithelium (RPE) injury is a key component of the outer blood retinal barrier, and its damage is an important indicator of DR. Receptor for activated C kinase 1 (RACK1) activates protein kinase C-ε (PKC-ε) to promote the generation of reactive oxygen species (ROS) in RPE cells, leading to apoptosis. Therefore, we hypothesize that the activation of RACK1 under hypoxic/high-glucose conditions may promote RPE cell apoptosis by modulating PKC-ε/ROS, thereby disrupting the barrier effect of the outer blood retinal barrier and contributing to the progression of DR.

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糖尿病和高血糖可上调视网膜中活化 C 激酶 1 受体的表达。

糖尿病视网膜病变（DR）是糖尿病的主要眼部并发症，可导致视力损伤。视网膜色素上皮（RPE）损伤是视网膜外血屏障的关键组成部分，其损伤是糖尿病视网膜病变的一个重要指标。活化C激酶1受体（RACK1）激活蛋白激酶C-ε（PKC-ε），促进RPE细胞中活性氧（ROS）的生成，导致细胞凋亡。因此，我们推测在缺氧/高血糖条件下，RACK1的激活可能会通过调节PKC-ε/ROS促进RPE细胞凋亡，从而破坏视网膜外血屏障的屏障效应，导致DR的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

自引率

2.40%

发文量

909

期刊介绍： The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.