A controversial question: Can morphometry and clinical history be enough to diagnose hippocampal dysplasia?

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

Epileptic Disorders Pub Date : 2024-04-08 DOI:10.1002/epd2.20222

Ianne Lucena Arruda, Rivus Ferreira Arruda, Rayanne Maria Brandão da Silveira, Jeana Torres Corso Duarte, Mirian Salvadori Bittar Guaranha, Laura Maria Guilhoto, Henrique Carrete Júnior, Joao Norberto Stavale, Ricardo Silva Centeno, Elza Marcia Targas Yacubian, Jose Eduardo Peixoto-Santos

引用次数: 0

Abstract

The presence of dysmorphic neurons with strong cytoplasmatic accumulation of heavy non-phosphorylated neurofilament is crucial for the diagnostics of focal cortical dysplasia type II (FCDII). While ILAE's classification describes neocortical dysplasias, some groups have reported patients with mesial t abnormal neurons in the hippocampus of mesial temporal lobe epilepsy. Here we report a patient with such abnormal neurons in the hippocampus and compared it with previous reports of hippocampal dysplasia. Finally, we discuss the need for diagnostic criteria of hippocampal dysplasia.

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一个有争议的问题：形态测量和临床病史足以诊断海马发育不良吗？

畸形神经元胞浆内大量积聚重型非磷酸化神经丝是诊断局灶性皮质发育不良 II 型（FCDII）的关键。虽然 ILAE 的分类描述的是新皮质发育不良，但也有一些研究小组报告了颞叶中叶癫痫患者的海马中侧 t 型异常神经元。在此，我们报告了一名海马神经元异常的患者，并将其与之前的海马发育不良报告进行了比较。最后，我们讨论了制定海马发育不良诊断标准的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epileptic Disorders 医学-临床神经学

CiteScore

4.10

自引率

8.70%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Epileptic Disorders is the leading forum where all experts and medical studentswho wish to improve their understanding of epilepsy and related disorders can share practical experiences surrounding diagnosis and care, natural history, and management of seizures. Epileptic Disorders is the official E-journal of the International League Against Epilepsy for educational communication. As the journal celebrates its 20th anniversary, it will now be available only as an online version. Its mission is to create educational links between epileptologists and other health professionals in clinical practice and scientists or physicians in research-based institutions. This change is accompanied by an increase in the number of issues per year, from 4 to 6, to ensure regular diffusion of recently published material (high quality Review and Seminar in Epileptology papers; Original Research articles or Case reports of educational value; MultiMedia Teaching Material), to serve the global medical community that cares for those affected by epilepsy.