Thymic Mimetic Cells: Ontogeny as Immunology

IF 11.4 1区 生物学 Q1 CELL BIOLOGY
Daniel A. Michelson, Diane Mathis
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引用次数: 0

Abstract

Medullary thymic epithelial cells (mTECs) generate immunological self-tolerance by ectopically expressing peripheral-tissue antigens (PTAs) within the thymus to preview the peripheral self to maturing T cells. Recent work, drawing inspiration from old histological observations, has shown that subtypes of mTECs, collectively termed mimetic cells, co-opt developmental programs from throughout the organism to express biologically coherent groups of PTAs. Here, we review key aspects of mimetic cells, especially as they relate to the larger contexts of molecular, cellular, developmental, and evolutionary biology. We highlight lineage-defining transcription factors as key regulators of mimetic cells and speculate as to what other factors, including Aire and the chromatin potential of mTECs, permit mimetic cell differentiation and function. Last, we consider what mimetic cells can teach us about not only the thymus but also other tissues.
胸腺模拟细胞:本体免疫学
胸腺髓质上皮细胞(mTECs)在胸腺内异位表达外周组织抗原(PTAs),向成熟的T细胞预告外周自身,从而产生免疫学上的自身耐受。最近的工作从古老的组织学观察中汲取灵感,显示出 mTECs 的亚型(统称为拟态细胞)共同采用了整个机体的发育程序,以表达生物学上一致的 PTAs 组。在此,我们回顾了拟态细胞的主要方面,特别是它们与分子、细胞、发育和进化生物学的大背景之间的关系。我们强调作为拟态细胞关键调控因子的品系界定转录因子,并推测还有哪些因素(包括 Aire 和 mTEC 的染色质潜能)允许拟态细胞分化和发挥功能。最后,我们将探讨拟态细胞不仅能为我们提供有关胸腺的知识,还能为我们提供有关其他组织的知识。
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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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