Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review).

IF 5.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

International journal of molecular medicine Pub Date : 2024-04-05 DOI:10.3892/ijmm.2024.5372

Yajing Zhan, Ankang Yin, Xiyang Su, Nan Tang, Zebin Zhang, Yi Chen, Wei Wang, Juan Wang

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引用次数: 0

Abstract

Histone chaperones serve a pivotal role in maintaining human physiological processes. They interact with histones in a stable manner, ensuring the accurate and efficient execution of DNA replication, repair and transcription. Retinoblastoma binding protein (RBBP)4 and RBBP7 represent a crucial pair of histone chaperones, which not only govern the molecular behavior of histones H3 and H4, but also participate in the functions of several protein complexes, such as polycomb repressive complex 2 and nucleosome remodeling and deacetylase, thereby regulating the cell cycle, histone modifications, DNA damage and cell fate. A strong association has been indicated between RBBP4/7 and some major human diseases, such as cancer, age‑related memory loss and infectious diseases. The present review assesses the molecular mechanisms of RBBP4/7 in regulating cellular biological processes, and focuses on the variations in RBBP4/7 expression and their potential mechanisms in various human diseases, thus providing new insights for their diagnosis and treatment.

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解读 RBBP4/7 的分子机制及其在人类疾病中的作用（综述）。

组蛋白伴侣在维持人体生理过程中发挥着关键作用。它们以稳定的方式与组蛋白相互作用，确保准确有效地进行 DNA 复制、修复和转录。视网膜母细胞瘤结合蛋白（RBBP）4 和 RBBP7 是一对重要的组蛋白伴侣，它们不仅调控组蛋白 H3 和 H4 的分子行为，还参与多聚胞抑制复合体 2 和核小体重塑及去乙酰化酶等多个蛋白复合物的功能，从而调控细胞周期、组蛋白修饰、DNA 损伤和细胞命运。有研究表明，RBBP4/7 与人类的一些重大疾病（如癌症、老年性记忆丧失和传染性疾病）密切相关。本综述评估了 RBBP4/7 在调控细胞生物学过程中的分子机制，并重点探讨了 RBBP4/7 在各种人类疾病中的表达变化及其潜在机制，从而为这些疾病的诊断和治疗提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of molecular medicine 医学-医学：研究与实验

CiteScore

12.30

自引率

0.00%

发文量

124

审稿时长

3 months

期刊介绍： The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.