Threonine fuels brain tumor growth through a conserved tRNA modification

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-04-02 DOI:10.1038/s43018-024-00750-z

引用次数: 0

Abstract

A CRISPR dropout screen for tRNA regulators identified YRDC as the top essential gene in glioblastoma stem cells. Threonine acts as a substrate of YRDC to facilitate the N6-threonylcarbamoyladenosine (t6A) tRNA modification and shift translation toward mitosis-related genes with a codon bias. Our findings support targeting glioblastoma growth by a well-tolerated dietary therapy.

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苏氨酸通过保守的 tRNA 修饰促进脑肿瘤生长

一项针对tRNA调节因子的CRISPR筛选发现，YRDC是胶质母细胞瘤干细胞中最重要的基因。苏氨酸是 YRDC 的底物，可促进 N6-苏氨酸氨基甲酰腺苷（t6A）tRNA 的修饰，并使翻译偏向于有丝分裂相关基因的密码子。我们的研究结果支持通过一种耐受性良好的饮食疗法来抑制胶质母细胞瘤的生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.