The effect of bone marrow derived cell therapies on hind limb perfusion, A systematic review and meta-analysis.

IF 4 3区医学 Q2 CELL BIOLOGY

Disease Models & Mechanisms Pub Date : 2024-04-15 DOI:10.1242/dmm.050632

F C C van Rhijn-Brouwer, K E Wever, R Kiffen, J R van Rhijn, H Gremmels, J O Fledderus, R W M Vernooij, M C Verhaar

引用次数: 0

Abstract

Administration of bone marrow (BM) derived cells to restore perfusion showed promising results in preclinical studies. However, clinical studies in chronic limb threatening ischemia (CLTI) demonstrated conflicting results. We conducted a systematic review and meta-analysis on preclinical studies to assess the efficacy of BM-derived cell administration in restoring relative perfusion in the hind limb ischemia model (HLI) and identify possible determinants of therapeutic efficacy.

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骨髓细胞疗法对后肢灌注的影响，系统回顾与荟萃分析。

在临床前研究中，使用骨髓（BM）衍生细胞来恢复灌注显示出良好的效果。然而，慢性肢体缺血（CLTI）的临床研究结果却相互矛盾。我们对临床前研究进行了系统回顾和荟萃分析，以评估骨髓衍生细胞在后肢缺血模型（HLI）中恢复相对灌注的疗效，并确定疗效的可能决定因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Disease Models & Mechanisms 医学-病理学

CiteScore

6.60

自引率

7.00%

发文量

203

审稿时长

6-12 weeks

期刊介绍： Disease Models & Mechanisms (DMM) is an online Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.