Kinesin Regulation in the Proximal Axon is Essential for Dendrite-selective Transport

Abstract

• Dendritic polarity is maintained by the arrest of dendrite-selective vesicles in the proximal axon, but the mechanism that mediates this arrest is unknown.

• The authors define a new molecular model of kinesin-3 family member KIF13A regulation by MARK2-mediated phosphorylation in the proximal axon. KIF13A is then recognized by 14-3-3 family members, resulting in kinesin-vesicle dissociation and termination of anterograde transport.

• These results indicate that regulation of kinesin binding to dendritic vesicles, rather than vesicle capture, is the key regulatory event that terminates anterograde transport of dendrite-selective vesicles at the base of the axon.