Setaria digitata infections in cattle: parasite load, microfilaraemia status and relationship to immune response

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-12 DOI:10.1017/s0022149x0070112x

M.C. Mohanty, P.K. Sahoo, A.K. Satapathy, B. Ravindran

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Abstract

A total of 110 cattle were examined in an area endemic for Bancroftian filariasis for the prevalence of infection of the bovine filarial parasite Setaria digitata. About 12.5% of cattle were found to harbour both adult worms in the peritoneum and microfilariae (mf) in circulation; 70% of the cattle were amicrofilaraemic but with an adult worm infection. A third group of cattle (16.5%) was free of detectable mf and adult worms. The presence of adult worms and/or mf did not influence the antibody levels to any of the four antigen preparations of S. digitata. However, there was a significant inverse relationship between the presence of antibodies to microfilarial sheaths and the absence of circulating mf as shown by the immunoperoxidase assay. Cattle immunoglobulin containing high titres of anti-sheath antibodies cleared circulating microfilariae very effectively in Mastomys coucha thus demonstrating the protective nature of anti-sheath antibodies in eliminating circulating microfilariae in vivo.

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牛的数字节肢动物感染：寄生虫量、微丝虫病状态以及与免疫反应的关系

在班氏丝虫病流行地区，共对 110 头牛进行了牛丝虫感染率检查。结果发现，约 12.5% 的牛腹膜中同时携带成虫和微丝蚴 (mf)；70% 的牛患有微丝蚴病，但有成虫感染。第三组牛（16.5%）没有检测到微丝蚴和成虫。成虫和/或 mf 的存在并不影响对 S. digitata 的四种抗原制剂中任何一种的抗体水平。然而，免疫过氧化物酶测定显示，微丝蚴鞘抗体的存在与循环中 mf 的缺失之间存在明显的反比关系。含有高滴度抗鞘抗体的牛免疫球蛋白能非常有效地清除库氏马斯托米虫体内的循环微丝蚴，从而证明了抗鞘抗体在消除体内循环微丝蚴方面的保护作用。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.