Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with risk of rheumatoid arthritis in the U.S. adult population

IF 5.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Health Pub Date : 2024-04-13 DOI:10.1186/s12940-024-01073-3

Jian-Chao Qiao, Zhen-Hua Li, Yu-Bo Ma, Hui-Ya Ma, Meng-Yue Zhang, Xiu-Jun Zhang, Cheng-Yang Hu

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引用次数: 0

Abstract

Per- and polyfluoroalkyl substances (PFAS) are known environmental contaminants with immunosuppressive properties. Their connection to rheumatoid arthritis (RA), a condition influenced by the immune system, is not well studied. This research explores the association between PFAS exposure and RA prevalence. This research utilized data from the NHANES, encompassing a sample of 10,496 adults from the 2003–2018 cycles, focusing on serum levels of several PFAS. The presence of RA was determined based on self-reports. This study used multivariable logistic regression to assess the relationship between individual PFAS and RA risk, adjusting for covariates to calculate odds ratios (ORs). The combined effects of PFAS mixtures were evaluated using BKMR, WQS regression, and quantile g-computation. Additionally, sex-specific associations were explored through stratified analysis. Higher serum PFOA (OR = 0.88, 95% CI: 0.79, 0.98), PFHxS (OR = 0.91, 95% CI: 0.83, 1.00), PFNA (OR = 0.87, 95% CI: 0.77, 0.98), and PFDA (OR = 0.89, 95% CI: 0.81, 0.99) concentration was related to lower odds of RA. Sex-specific analysis in single chemical models indicated the significant inverse associations were only evident in females. BKMR did not show an obvious pattern of RA estimates across PFAS mixture. The outcomes of sex-stratified quantile g-computation demonstrated that an increase in PFAS mixture was associated with a decreased odds of RA in females (OR: 0.76, 95% CI: 0.62, 0.92). We identified a significant interaction term of the WQS*sex in the 100 repeated hold out WQS analysis. Notably, a higher concentration of the PFAS mixture was significantly associated with reduced odds of RA in females (mean OR = 0.93, 95% CI: 0.88, 0.98). This study indicates potential sex-specific associations of exposure to various individual PFAS and their mixtures with RA. Notably, the observed inverse relationships were statistically significant in females but not in males. These findings contribute to the growing body of evidence indicating that PFAS may have immunosuppressive effects.

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全氟烷基和多氟烷基物质 (PFAS) 及其混合物与美国成年人群类风湿性关节炎风险的关系

全氟和多氟烷基物质（PFAS）是已知的具有免疫抑制特性的环境污染物。它们与类风湿性关节炎（RA）（一种受免疫系统影响的疾病）之间的关系尚未得到充分研究。本研究探讨了 PFAS 暴露与 RA 患病率之间的关系。这项研究利用了美国国家健康调查（NHANES）的数据，涵盖了 2003-2018 年期间的 10,496 个成人样本，重点研究了几种全氟辛烷磺酸的血清水平。根据自我报告确定是否患有 RA。本研究采用多变量逻辑回归法评估单个 PFAS 与 RA 风险之间的关系，并对协变量进行调整，计算出几率比（ORs）。使用 BKMR、WQS 回归和量化 g 计算评估了 PFAS 混合物的综合效应。此外，还通过分层分析探讨了性别特异性关联。血清中 PFOA（OR = 0.88，95% CI：0.79，0.98）、PFHxS（OR = 0.91，95% CI：0.83，1.00）、PFNA（OR = 0.87，95% CI：0.77，0.98）和 PFDA（OR = 0.89，95% CI：0.81，0.99）浓度越高，患 RA 的几率越低。在单一化学模型中进行的性别特异性分析表明，显著的反向关联仅在女性中明显。BKMR在PFAS混合物中未显示出明显的RA估计模式。性别分层量化 g 计算的结果表明，PFAS 混合物的增加与女性罹患 RA 的几率降低相关（OR：0.76，95% CI：0.62，0.92）。在 100 次重复保持 WQS 分析中，我们发现了 WQS* 性别的重要交互项。值得注意的是，PFAS 混合物浓度越高，女性患 RA 的几率越低（平均 OR = 0.93，95% CI：0.88, 0.98）。这项研究表明，暴露于各种个别的全氟辛烷磺酸及其混合物与 RA 之间可能存在性别特异性关联。值得注意的是，观察到的反向关系在女性中具有统计学意义，而在男性中则没有。越来越多的证据表明，全氟辛烷磺酸可能具有免疫抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Health 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

10.10

自引率

1.70%

发文量

115

审稿时长

3.0 months

期刊介绍： Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.