Antibody response to malaria vaccine candidates in pregnant women with Plasmodium falciparum and Schistosoma haematobium infections

IF 1.4 4区医学 Q4 IMMUNOLOGY

Parasite Immunology Pub Date : 2024-04-08 DOI:10.1111/pim.13027

Naa Adjeley Frempong, Atikatou Mama, Bright Adu, Kwadwo Asamoah Kusi, Michael F. Ofori, Charity Ahiabor, William K. Anyan, Alex Yaw Debrah, Abraham A. Anang, Nicaise T. Ndam, David Courtin

{"title":"Antibody response to malaria vaccine candidates in pregnant women with Plasmodium falciparum and Schistosoma haematobium infections","authors":"Naa Adjeley Frempong, Atikatou Mama, Bright Adu, Kwadwo Asamoah Kusi, Michael F. Ofori, Charity Ahiabor, William K. Anyan, Alex Yaw Debrah, Abraham A. Anang, Nicaise T. Ndam, David Courtin","doi":"10.1111/pim.13027","DOIUrl":null,"url":null,"abstract":"Malaria in pregnancy has severe consequences for the mother and foetus. Antibody response to specific malaria vaccine candidates (MVC) has been associated with a decreased risk of clinical malaria and its outcomes. We studied Plasmodium falciparum (Pf) and Schistosoma haematobium (Sh) infections and factors that could influence antibody responses to MVC in pregnant women. A total of 337 pregnant women receiving antenatal care (ANC) and 139 for delivery participated in this study. Pf infection was detected by qPCR and Sh infection using urine filtration method. Antibody levels against CSP, AMA‐1, GLURP‐R0, VAR2CSA and Pfs48/45 MVC were quantified by ELISA. Multivariable linear regression models identified factors associated with the modulation of antibody responses. The prevalence of Pf and Sh infections was 27% and 4% at ANC and 7% and 4% at delivery. Pf infection, residing in Adidome and multigravidae were positively associated with specific IgG response to CSP, AMA‐1, GLURP‐R0 and VAR2CSA. ITN use and IPTp were negatively associated with specific IgG response to GLURP‐R0 and Pfs48/45. There was no association between Sh infection and antibody response to MVC at ANC or delivery. Pf infections in pregnant women were positively associated with antibody response to CSP, GLURP‐R0 and AMA‐1. Antibody response to GLURP‐R0 and Pfs48/45 was low for IPTp and ITN users. This could indicate a lower exposure to Pf infection and low malaria prevalence observed at delivery.","PeriodicalId":19931,"journal":{"name":"Parasite Immunology","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parasite Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/pim.13027","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Malaria in pregnancy has severe consequences for the mother and foetus. Antibody response to specific malaria vaccine candidates (MVC) has been associated with a decreased risk of clinical malaria and its outcomes. We studied Plasmodium falciparum (Pf) and Schistosoma haematobium (Sh) infections and factors that could influence antibody responses to MVC in pregnant women. A total of 337 pregnant women receiving antenatal care (ANC) and 139 for delivery participated in this study. Pf infection was detected by qPCR and Sh infection using urine filtration method. Antibody levels against CSP, AMA‐1, GLURP‐R0, VAR2CSA and Pfs48/45 MVC were quantified by ELISA. Multivariable linear regression models identified factors associated with the modulation of antibody responses. The prevalence of Pf and Sh infections was 27% and 4% at ANC and 7% and 4% at delivery. Pf infection, residing in Adidome and multigravidae were positively associated with specific IgG response to CSP, AMA‐1, GLURP‐R0 and VAR2CSA. ITN use and IPTp were negatively associated with specific IgG response to GLURP‐R0 and Pfs48/45. There was no association between Sh infection and antibody response to MVC at ANC or delivery. Pf infections in pregnant women were positively associated with antibody response to CSP, GLURP‐R0 and AMA‐1. Antibody response to GLURP‐R0 and Pfs48/45 was low for IPTp and ITN users. This could indicate a lower exposure to Pf infection and low malaria prevalence observed at delivery.

查看原文本刊更多论文

恶性疟原虫和血吸虫感染孕妇对候选疟疾疫苗的抗体反应

妊娠期疟疾会对母亲和胎儿造成严重后果。对特定疟疾疫苗候选物（MVC）的抗体反应与临床疟疾风险的降低及其结果有关。我们研究了恶性疟原虫（Pf）和血吸虫（Sh）感染以及可能影响孕妇对 MVC 产生抗体反应的因素。共有 337 名孕妇接受了产前检查（ANC），139 名孕妇进行了分娩。用 qPCR 检测 Pf 感染，用尿液过滤法检测 Sh 感染。用酶联免疫吸附法对 CSP、AMA-1、GLURP-R0、VAR2CSA 和 Pfs48/45 MVC 的抗体水平进行了量化。多变量线性回归模型确定了与抗体反应调节相关的因素。在产前检查时，Pf和Sh感染率分别为27%和4%，在分娩时分别为7%和4%。Pf感染、居住在Adidome和多胎妊娠与对CSP、AMA-1、GLURP-R0和VAR2CSA的特异性IgG反应呈正相关。使用 ITN 和 IPTp 与对 GLURP-R0 和 Pfs48/45 的特异性 IgG 反应呈负相关。Sh 感染与产前检查或分娩时对 MVC 的抗体反应没有关联。孕妇的 Pf 感染与 CSP、GLURP-R0 和 AMA-1 的抗体反应呈正相关。使用 IPTp 和 ITN 的孕妇对 GLURP-R0 和 Pfs48/45 的抗体反应较低。这可能表明孕妇在分娩时受到的疟原虫感染较少，疟疾流行率较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Parasite Immunology 医学-寄生虫学

CiteScore

4.70

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Parasite Immunology is an international journal devoted to research on all aspects of parasite immunology in human and animal hosts. Emphasis has been placed on how hosts control parasites, and the immunopathological reactions which take place in the course of parasitic infections. The Journal welcomes original work on all parasites, particularly human parasitology, helminths, protozoa and ectoparasites.