Plasma biomarkers for predicting the development of dementia in a community-dwelling older Japanese population

IF 5 3区医学 Q1 CLINICAL NEUROLOGY

Psychiatry and Clinical Neurosciences Pub Date : 2024-04-12 DOI:10.1111/pcn.13661

Tomoyuki Ohara, Harutsugu Tatebe, Jun Hata, Takanori Honda, Mao Shibata, Sayo Matsuura, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Takahiko Tokuda, Toshiharu Ninomiya

引用次数: 0

Abstract

To assess the association between plasma amyloid β (Aβ) 42/40, phosphorylated tau (p-τ)181, glial fibrillary acidic protein (GFAP), or neurofilament light chain (NfL) and the risk of dementia and to determine whether these plasma biomarkers could improve the ability to predict incident dementia in a general older population.

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预测日本社区老年人痴呆症发展的血浆生物标志物

目的：评估血浆淀粉样蛋白β（Aβ）42/40、磷酸化tau（p-τ）181、神经纤维酸性蛋白（GFAP）或神经丝轻链（NfL）与痴呆症风险之间的关系，并确定这些血浆生物标志物是否能提高预测普通老年人群中痴呆症发病的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry and Clinical Neurosciences 医学-精神病学

CiteScore

7.40

自引率

4.20%

发文量

181

审稿时长

6-12 weeks

期刊介绍： PCN (Psychiatry and Clinical Neurosciences) Publication Frequency: Published 12 online issues a year by JSPN Content Categories: Review Articles Regular Articles Letters to the Editor Peer Review Process: All manuscripts undergo peer review by anonymous reviewers, an Editorial Board Member, and the Editor Publication Criteria: Manuscripts are accepted based on quality, originality, and significance to the readership Authors must confirm that the manuscript has not been published or submitted elsewhere and has been approved by each author