Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery

IF 1.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Medicinal Chemistry Pub Date : 2024-04-04 DOI:10.2174/0115734064277371240325105016

Archana Sharma, Twinkle Sharma, Rajveer Bhaskar, Monika Ola, Alok Sharma, Vijay Kumar Thakur, Prabodh Chander Sharma

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Abstract

: Viruses are acellular, microscopic, and mobile particles containing genetic particles, either DNA/RNA strands as nucleoproteins, responsible for 69,53,743 deaths till the year 2023. Curcumin and related compounds are among the areas of pivotal interest for researchers because of their versatile pharmacological profile. Chemically known as diferuloylmethane, which is a main constituent of turmeric along with demethoxycurcumin and bisdemethoxycurcumin, they have a broad spectrum of antiviral activity against viruses such as human immunodeficiency virus, herpes simplex virus, influenza virus (Avian influenza) and Hepatitis C virus HIV. The possible role of curcumin as an antiviral agent may be attributed to the activation of the 20S proteasome, a cellular machinery responsible for degrading unfolded or misfolded proteins in a ubiquitin-independent manner. It shows suppression of HBV entry at various infection stages by inhibiting cccDNA replication by inhibiting the Wnt/β-catenin signaling pathway to attenuate IAV-induced myocarditis.

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姜黄素及相关化合物在抗病毒药物研发中的巨大潜力

:病毒是一种无细胞的、微小的、可移动的颗粒，含有遗传颗粒（DNA/RNA 链或核蛋白），到 2023 年，造成 69,53,743 人死亡。姜黄素及相关化合物因其多变的药理特性而成为研究人员关注的焦点之一。姜黄素与去甲氧基姜黄素和双去甲氧基姜黄素的化学名称是二姜黄酰甲烷，是姜黄的主要成分，它们对人类免疫缺陷病毒、单纯疱疹病毒、流感病毒（禽流感）和丙型肝炎病毒等病毒具有广谱的抗病毒活性。姜黄素之所以能起到抗病毒作用，可能是因为它激活了 20S 蛋白酶体，这是一种细胞机制，负责以不依赖泛素的方式降解未折叠或折叠错误的蛋白质。它通过抑制 Wnt/β-catenin 信号通路来抑制cccDNA复制，从而抑制 HBV 在不同感染阶段的进入，从而减轻 IAV 引起的心肌炎。

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来源期刊

Medicinal Chemistry 医学-医药化学

CiteScore

4.30

自引率

4.30%

发文量

109

审稿时长

12 months

期刊介绍： Aims & Scope Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.