Ramifications of m6A Modification on ncRNAs in Cancer

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-15 DOI:10.2174/0113892029296712240405053201

Rashid Mehmood

引用次数: 0

Abstract

:: N6-methyladenosine (m6A) is an RNA modification wherein the N6-position of adenosine is methylated. It is one of the most prevalent internal modifications of RNA and regulates various aspects of RNA metabolism. M6A is deposited by m6A methyltransferases, removed by m6A demethylases, and recognized by reader proteins, which modulate splicing, export, translation, and stability of the modified mRNA. Recent evidence suggests that various classes of non-- coding RNAs (ncRNAs), including microRNAs (miRNAs), circular RNAs (circRNAs), and long con-coding RNAs (lncRNAs), are also targeted by this modification. Depending on the ncRNA species, m6A may affect the processing, stability, or localization of these molecules. The m6A-- modified ncRNAs are implicated in a number of diseases, including cancer. In this review, the author summarizes the role of m6A modification in the regulation and functions of ncRNAs in tumor development. Moreover, the potential applications in cancer prognosis and therapeutics are discussed.

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m6A 修饰对癌症中 ncRNA 的影响

::N6-甲基腺苷（m6A）是一种 RNA 修饰，其中腺苷的 N6 位被甲基化。它是 RNA 最常见的内部修饰之一，调节着 RNA 代谢的各个方面。M6A 由 m6A 甲基转移酶沉积，由 m6A 去甲基化酶去除，并被阅读蛋白识别，从而调节经修饰的 mRNA 的剪接、输出、翻译和稳定性。最近的证据表明，各种非编码 RNA（ncRNA），包括微 RNA（miRNA）、环状 RNA（circRNA）和长共编码 RNA（lncRNA），也是这种修饰的靶标。根据 ncRNA 种类的不同，m6A 可能会影响这些分子的加工、稳定性或定位。经 m6A 修饰的 ncRNA 与癌症等多种疾病有关。在这篇综述中，作者总结了 m6A 修饰在肿瘤发生过程中 ncRNAs 的调控和功能中的作用。此外，还讨论了在癌症预后和治疗中的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.