A Comprehensive Guide to the Development, Evaluation, and Future Prospects of Self-nanoemulsifying Drug Delivery Systems for Poorly Water-soluble Drugs

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current pharmaceutical design Pub Date : 2024-04-15 DOI:10.2174/0113816128296705240327065131

Abhishek Chauhan, Raj Kamal, Ritika Mishra, Devank Shekho, Ankit Awasthi

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引用次数: 0

Abstract

:: Self-Nano Emulsifying Drug Delivery Systems (SNEDDS) are novel formulations that can enhance the solubility and bioavailability of poorly water-soluble drugs. SNEDDS are composed of lipids, surfactants, co-solvents, and drugs and can spontaneously form nanoemulsions when mixed with water under mild agitation. SNEDDS can be formulated as liquid or solid dosage forms and can improve drug absorption by increasing the interfacial area, protecting the drug from degradation, and facilitating lymphatic transport. SNEDDS is characterized by various parameters such as particle size, zeta potential, droplet morphology, emulsification efficiency, drug solubility, and stability. SNEDDS offers several advantages over conventional dosage forms, such as dose reduction, faster onset of action, reduced variability, versatility, and ease of formulation. However, SNEDDS also face some limitations and challenges, such as drug precipitation, cost-effectiveness, compatibility with capsule shells, and lack of predictive in vitro models. SNEDDS has a promising future in the field of pharmaceuticals, especially for personalized medicine and targeted drug delivery.

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针对水溶性差药物的自纳米乳化给药系统的开发、评估和未来展望综合指南

::自纳米乳化给药系统（SNEDDS）是一种新型制剂，可提高水溶性差的药物的溶解度和生物利用度。自纳米乳化给药系统由脂质、表面活性剂、助溶剂和药物组成，在轻度搅拌下与水混合后可自发形成纳米乳液。SNEDDS 可配制成液体或固体剂型，可通过增加界面面积、保护药物不被降解和促进淋巴转运来改善药物吸收。SNEDDS 具有多种参数特征，如粒度、zeta 电位、液滴形态、乳化效率、药物溶解度和稳定性。与传统剂型相比，SNEDDS 具有多种优势，如剂量减少、起效更快、变异性降低、用途广泛和易于配制。不过，SNEDDS 也面临一些限制和挑战，如药物沉淀、成本效益、与胶囊壳的兼容性以及缺乏预测性体外模型等。SNEDDS 在制药领域，尤其是个性化医疗和靶向给药领域前景广阔。

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.