Xue Wang, Yanli Zhu, Xiaojuan Ma, Jun Ren, Yang Yan, Yanqing Liu, Heng Gao, Shaofei Zhang, Ying Chen, Yang Yang, Chao Deng
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引用次数: 0
Abstract
Type A acute aortic dissection (TA-AAD) patients are prone to life-threatening complications and death. This study aimed to analyze the association between eosinophil (EOS) recovery and clinical outcomes in TA-AAD. A total of 274 patients with TA-AAD were eligible for inclusion, and 54 patients died within 1 month. The patients with poor clinical outcomes showed significantly lower EOS count within 8 days after surgery. The time-dependent ROC analysis showed that EOS recovery days predicted 1-month death with an AUC of 0.886 and a cutoff of 6 days. EOS recovery within 6 days was associated with a lower incidence of postoperative infection, a poorer prognosis, and a lower risk of 1-month and 6-month mortality than those requiring more recovery days. Collectively, postoperative early recovery of EOS predicted lower mortality and better prognosis and may be applied as an effective, rapid, and simple tool for the risk stratification and prognostic prediction of patients with TA-AAD.
A 型急性主动脉夹层（TA-AAD）患者容易出现危及生命的并发症和死亡。本研究旨在分析嗜酸性粒细胞（EOS）恢复与TA-AAD临床预后之间的关系。共有274名TA-AAD患者符合纳入条件，其中54名患者在1个月内死亡。临床疗效不佳的患者在术后8天内嗜酸性粒细胞计数明显降低。时间依赖性ROC分析显示，EOS恢复天数预测1个月内死亡的AUC为0.886，截止时间为6天。与需要更多恢复天数的患者相比，6 天内恢复 EOS 与术后感染发生率较低、预后较差以及 1 个月和 6 个月死亡风险较低有关。总之，术后早期恢复 EOS 预测了较低的死亡率和较好的预后，可作为一种有效、快速、简单的工具用于 TA-AAD 患者的风险分层和预后预测：临床试验注册号：NCT05409677.图文摘要
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