Post-radiation middle ear effusion in NPC patients: Analysis of patient, tumour, and radiation factors

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY

Clinical Otolaryngology Pub Date : 2024-04-04 DOI:10.1111/coa.14159

Igor Vainer, Sharon Tzelnick, Noga Kurman, Aron Popovtzer, Ethan Soudry

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Abstract

Objective

The purpose of this study was to investigate whether patient, tumour and radiation therapy factors are associated with development of middle ear effusion (MEE) in nasopharyngeal carcinoma (NPC) patients.

Deign, Settings, and Participants

A retrospective review of NPC patients treated between January 2000 and June 2018 at Rabin Medical Center.

Patient factors, tumour factors, radiation doses, and radiation fields were collected and outlined if needed (middle ear, eustachian tube [ET], tensor veli palatini [TVP], and levator palatini [LVP] muscles), then analysed and compared between patients with MEE and those without and between sides in patients with unilateral MEE.

Main Outcome Measures and Results

Seventy-three patients were enrolled. Most were males (71.2%) with advanced-stage diseases (78%). At the time of diagnosis 14 patients (19.2%) presented with MEE. Following radiation, 18 patients, with no evidence of MEE at presentation, developed MEE. Tumour stage, histology, and laterality were not associated with development of MEE. Comparison of mean radiation field dosages including—gross target volume, clinical target volume, and patient target volume showed no association with post-radiation MEE. In addition, no difference was found in the radiation doses to the middle ear, ET or the LVP nor the TVP between ears with and without MEE.

Conclusions

Post-irradiation MEE remains a common adverse effect in NPC patients. Surprisingly, tumour stage, tumour laterality, and histology were not associated with MEE. Similar findings were observed for total radiation doses and specific doses to the middle ear, ET, and ET muscles.

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鼻咽癌患者放疗后中耳积液：患者、肿瘤和辐射因素分析

本研究旨在调查患者、肿瘤和放疗因素是否与鼻咽癌（NPC）患者中耳积液（MEE）的发生有关。收集患者因素、肿瘤因素、辐射剂量和辐射野，并在必要时概述（中耳、咽鼓管 [ET]、腭张肌 [TVP] 和腭侧肌 [LVP]），然后分析和比较有 MEE 和无 MEE 患者之间以及单侧 MEE 患者两侧之间的情况。大多数患者为男性（71.2%），疾病处于晚期（78%）。确诊时，14 名患者（19.2%）伴有 MEE。在接受放射治疗后，有 18 名患者出现了 MEE，这些患者在确诊时没有 MEE 的迹象。肿瘤分期、组织学和侧位与 MEE 的发生无关。对包括总目标体积、临床目标体积和患者目标体积在内的平均放射野剂量进行比较后发现，这些剂量与放疗后 MEE 无关。此外，中耳、ET 或 LVP 的辐射剂量以及 TVP 在有 MEE 和没有 MEE 的耳朵之间也没有差异。令人惊讶的是，肿瘤分期、肿瘤侧位和组织学与 MEE 无关。中耳、ET和ET肌肉的总辐射剂量和特定剂量也有类似的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.