Oral pH triggered colon-specific ketoprofen loaded microspheres for the better management of early morning symptoms associated with rheumatoid arthritis. Part I: Optimization, in-vitro, and ex-vivo characterization

IF 1.9 4区化学 Q4 CHEMISTRY, PHYSICAL

Journal of Dispersion Science and Technology Pub Date : 2024-04-09 DOI:10.1080/01932691.2024.2338359

Krishna Sanka, Prabhakar Reddy Veerareddy, Rajeswara Rao Pragada

引用次数: 0

Abstract

The primary goal of this research was to investigate pH-triggered colon-specific ketoprofen-loaded microspheres (C-SKLM) using Eudragit S-100 as a pH-dependent polymer. The formulation was optimize...

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口服 pH 触发的结肠特异性酮洛芬负载微球，用于更好地治疗类风湿性关节炎相关的清晨症状。第一部分：优化、体外和体内表征

这项研究的主要目的是利用Eudragit S-100作为pH值依赖性聚合物，研究pH值触发的结肠特异性酮洛芬负载微球（C-SKLM）。对配方进行了优化...

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Dispersion Science and Technology 化学-物理化学

CiteScore

5.00

自引率

4.50%

发文量

140

审稿时长

1.1 months

期刊介绍： Journal of Dispersion Science and Technology is an international journal covering fundamental and applied aspects of dispersions, emulsions, vesicles, microemulsions, liquid crystals, particle suspensions and sol-gel processes. Fundamental areas that are covered include new surfactants, polymers and indigenous stabilizers; surfactant and polymer association as well as phase equilibria in systems water and oil; surfactant and polymer films, monolayers and interfacial films; adsorption and desorption onto solid surfaces; stability and destabilization of dispersions, emulsions and particle suspensions; collodal templates and sol-gel processing. Industrial applications cover chemicals, crude oils, food, pharmaceuticals, agriculture, nanotechnology, and soft condensed materials.