Inside Front Cover: Cerebrospinal fluid efflux through dynamic paracellular pores on venules as a missing piece of the brain drainage system (EXP2 2/2024)
{"title":"Inside Front Cover: Cerebrospinal fluid efflux through dynamic paracellular pores on venules as a missing piece of the brain drainage system (EXP2 2/2024)","authors":"Yaqiong Dong, Ting Xu, Lan Yuan, Yahan Wang, Siwang Yu, Zhi Wang, Shizhu Chen, Chunhua Chen, Weijiang He, Tessandra Stewart, Weiguang Zhang, Xiaoda Yang","doi":"10.1002/EXP.20240202","DOIUrl":null,"url":null,"abstract":"<p>While asleep, the cerebrospinal fluid (CSF) flush over the brain parenchyma via pathways generated by neuroglia cells. The interstitial fluid (ISF) solutes containing metabolic wastes/toxins such as Aβ are collected in the paravenous space, where the CSF-ISF fluid eventually exit into blood through dynamically assembled, trumpet-shaped pores formed by vascular endothelial cells.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240202","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exploration (Beijing, China)","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/EXP.20240202","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
While asleep, the cerebrospinal fluid (CSF) flush over the brain parenchyma via pathways generated by neuroglia cells. The interstitial fluid (ISF) solutes containing metabolic wastes/toxins such as Aβ are collected in the paravenous space, where the CSF-ISF fluid eventually exit into blood through dynamically assembled, trumpet-shaped pores formed by vascular endothelial cells.