Two new pregnane glycosides from the flower buds of Dregea volubilis

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-04-17 DOI:10.1016/j.phytol.2024.04.006

Xiao-Dong Zhang , Bin Qiu , Jie Yu , Ni-Man Bao

引用次数: 0

Abstract

Two new pregnane glycosides, drevoluoside R (1) and drevoluoside S (2), along with one known analogue, degeoside A_a1 (3), were isolated from the fresh flower buds of Dregea. volubilis. The structures of the new metabolites were established on the basis of detailed spectroscopic analysis. Compounds 1–3 were evaluated for their cytotoxicity against five human cancer cell lines with cisplantin as a positive control.

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从 Dregea volubilis 的花蕾中提取的两种新的孕烷苷

从 Dregea. volubilis 的新鲜花蕾中分离出了两种新的孕烷苷，drevoluoside R（1）和 drevoluoside S（2），以及一种已知的类似物 degeoside Aa1（3）。新代谢物的结构是在详细的光谱分析基础上确定的。以顺皂甙为阳性对照，评估了化合物 1-3 对五种人类癌细胞株的细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.