Tetrahedral framework nucleic acids/hyaluronic acid-methacrylic anhydride hybrid hydrogel with antimicrobial and anti-inflammatory properties for infected wound healing

IF 10.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Cai Qi, Qiang Sun, Dexuan Xiao, Mei Zhang, Shaojingya Gao, Bin Guo, Yunfeng Lin
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Abstract

Bacterial resistance and excessive inflammation are common issues that hinder wound healing. Antimicrobial peptides (AMPs) offer a promising and versatile antibacterial option compared to traditional antibiotics, with additional anti-inflammatory properties. However, the applications of AMPs are limited by their antimicrobial effects and stability against bacterial degradation. TFNAs are regarded as a promising drug delivery platform that could enhance the antibacterial properties and stability of nanodrugs. Therefore, in this study, a composite hydrogel (HAMA/t-GL13K) was prepared via the photocross-linking method, in which tFNAs carry GL13K. The hydrogel was injectable, biocompatible, and could be instantly photocured. It exhibited broad-spectrum antibacterial and anti-inflammatory properties by inhibiting the expression of inflammatory factors and scavenging ROS. Thereby, the hydrogel inhibited bacterial infection, shortened the wound healing time of skin defects in infected skin full-thickness defect wound models and reduced scarring. The constructed HAMA/tFNA-AMPs hydrogels exhibit the potential for clinical use in treating microbial infections and promoting wound healing.

Abstract Image

具有抗菌消炎特性的四面体框架核酸/透明质酸-甲基丙烯酸酐杂化水凝胶,用于感染伤口愈合
细菌耐药性和过度炎症是阻碍伤口愈合的常见问题。与传统抗生素相比,抗菌肽(AMPs)提供了一种前景广阔的多功能抗菌选择,并具有额外的抗炎特性。然而,AMPs 的应用受到其抗菌效果和抗细菌降解稳定性的限制。TFNA 被认为是一种很有前景的给药平台,可以增强纳米药物的抗菌性能和稳定性。因此,本研究通过光交联法制备了一种复合水凝胶(HAMA/t-GL13K),其中 tFNAs 带有 GL13K。该水凝胶可注射,生物相容性好,可瞬间光固化。它通过抑制炎症因子的表达和清除 ROS,表现出广谱抗菌和抗炎特性。因此,该水凝胶可抑制细菌感染,缩短感染性皮肤全厚缺损伤口模型的伤口愈合时间,并减少瘢痕形成。所构建的 HAMA/tFNA-AMPs 水凝胶具有治疗微生物感染和促进伤口愈合的临床应用潜力。
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来源期刊
International Journal of Oral Science
International Journal of Oral Science DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
31.80
自引率
1.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: The International Journal of Oral Science covers various aspects of oral science and interdisciplinary fields, encompassing basic, applied, and clinical research. Topics include, but are not limited to: Oral microbiology Oral and maxillofacial oncology Cariology Oral inflammation and infection Dental stem cells and regenerative medicine Craniofacial surgery Dental material Oral biomechanics Oral, dental, and maxillofacial genetic and developmental diseases Craniofacial bone research Craniofacial-related biomaterials Temporomandibular joint disorder and osteoarthritis The journal publishes peer-reviewed Articles presenting new research results and Review Articles offering concise summaries of specific areas in oral science.
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