A simplified longitudinal model for the development of Type 2 Diabetes Mellitus

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-07 DOI:10.1016/j.jtbi.2024.111822

Andrea De Gaetano , Ilona Nagy , Daniel Kiss , Valery G. Romanovski , Thomas A. Hardy

引用次数: 0

Abstract

Obesity and diabetes are a progressively more and more deleterious hallmark of modern, well fed societies. In order to study the potential impact of strategies designed to obviate the pathological consequences of detrimental lifestyles, a model for the development of Type 2 diabetes geared towards large population simulations would be useful. The present work introduces such a model, representing in simplified fashion the interplay between average glycemia, average insulinemia and functional beta-cell mass, and incorporating the effects of excess food intake or, conversely, of physical activity levels. Qualitative properties of the model are formally established and simulations are shown as examples of its use.

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2 型糖尿病发展的简化纵向模型

肥胖症和糖尿病是现代丰衣足食社会日益严重的标志。为了研究旨在避免有害生活方式造成的病理后果的策略可能产生的影响，一个针对大规模人群模拟的 2 型糖尿病发展模型将非常有用。本研究介绍了这样一个模型，它以简化的方式表示了平均血糖、平均胰岛素血症和功能性β细胞质量之间的相互作用，并纳入了过量食物摄入或相反的体力活动水平的影响。本文正式确定了该模型的定性属性，并通过模拟示例说明了该模型的使用情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.