Consumption of cow's milk formula in the nursery and the development of milk allergy

IF 4.6 2区医学 Q2 ALLERGY

Clinical and Translational Allergy Pub Date : 2024-04-12 DOI:10.1002/clt2.12352

Arnon Elizur, Shirel Rachel-Jossefi, Marianna Rachmiel, Eli Eisenberg, Yitzhak Katz

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Abstract

Background

The effect of the amount of transient cow's milk formula (CMF) consumed during the first days of life on IgE-cow's milk allergy (IgE-CMA) is unknown.

Methods

A cohort of 58 patients with IgE-CMA was identified from a large scale population-based study of 13,019 infants followed from birth. A group of 116 infants matched for sex and breastfeeding only duration (beyond the nursery period), and another random group of 259 healthy infants were used as controls. Parents were interviewed and the infants' medical records were searched to assess CMF consumption in the nursery.

Results

While 96% of the mothers of the 174 infants (58 with Cow's milk allergy and 116 controls) reported on exclusive breastfeeding during the stay in the nursery, CMF consumption was documented in 96 (55%) of the infants. Of those, most (57; 59%) received one to three feedings, 20 (21%) received four to nine feedings, and 19 (20%) received ≥10 feedings. Fewer formula feeds (1–3) were significantly more common in the allergic group than ≥4 feeds (p = 0.0003) and no feeds at all (p = 0.02) compared to controls (n = 116). Of those exclusively breastfed in the nursery, 13/23 allergic infants (57%) introduced CMF at age 105–194 days (the period with highest-risk for IgE-CMA) compared to 33/98 (34%) from the random control group (n = 259) (p = 0.04).

Conclusions

Most infants end up receiving few CMF feeds in the nursery. Transient CMF in the nursery is associated with increased risk of IgE-CMA.

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在婴儿期食用牛奶配方奶粉与牛奶过敏症的发生

背景出生后最初几天食用的短暂牛乳配方奶（CMF）量对 IgE-牛乳过敏（IgE-CMA）的影响尚不清楚。方法在对 13,019 名婴儿进行的大规模人群研究中，发现了 58 名 IgE-CMA 患者。一组是性别和母乳喂养时间（超过育婴期）相匹配的 116 名婴儿，另一组是随机抽取的 259 名健康婴儿，作为对照组。研究人员对父母进行了访谈，并对婴儿的医疗记录进行了检索，以评估婴儿在育婴期间的 CMF 消费情况。结果在 174 名婴儿（58 名牛乳过敏婴儿和 116 名对照组婴儿）的母亲中，96% 的母亲表示在婴儿保育院期间进行了纯母乳喂养，96 名婴儿（55%）食用了 CMF。其中，大多数婴儿（57；59%）喂食一至三次，20（21%）喂食四至九次，19（20%）喂食≥十次。与对照组（n = 116）相比，过敏组配方奶喂养次数较少（1-3 次）的情况明显多于喂养次数≥4 次（p = 0.0003）和完全不喂养（p = 0.02）的情况。在育婴室纯母乳喂养的婴儿中，有 13/23 名过敏婴儿（57%）在 105-194 天时（IgE-CMA 风险最高的时期）添加了 CMF，而随机对照组（n = 259）中有 33/98 名婴儿（34%）添加了 CMF（p = 0.04）。结论大多数婴儿最终在保育室接受的 CMF 喂养很少。育婴室中短暂的 CMF 与 IgE-CMA 风险增加有关。

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来源期刊

Clinical and Translational Allergy Immunology and Microbiology-Immunology

CiteScore

7.50

自引率

4.50%

发文量

117

审稿时长

12 weeks

期刊介绍： Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.