Relating pre-treatment non-Gaussian intravoxel incoherent motion diffusion-weighted imaging to human papillomavirus status and response in oropharyngeal carcinoma

IF 3.4 Q2 ONCOLOGY
Nienke D. Sijtsema , Iris Lauwers , Gerda M. Verduijn , Mischa S. Hoogeman , Dirk H.J. Poot , Juan A. Hernandez-Tamames , Aad van der Lugt , Marta E. Capala , Steven F. Petit
{"title":"Relating pre-treatment non-Gaussian intravoxel incoherent motion diffusion-weighted imaging to human papillomavirus status and response in oropharyngeal carcinoma","authors":"Nienke D. Sijtsema ,&nbsp;Iris Lauwers ,&nbsp;Gerda M. Verduijn ,&nbsp;Mischa S. Hoogeman ,&nbsp;Dirk H.J. Poot ,&nbsp;Juan A. Hernandez-Tamames ,&nbsp;Aad van der Lugt ,&nbsp;Marta E. Capala ,&nbsp;Steven F. Petit","doi":"10.1016/j.phro.2024.100574","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and purpose</h3><p>Diffusion-weighted imaging (DWI) is a promising technique for response assessment in head-and-neck cancer. Recently, we optimized Non-Gaussian Intravoxel Incoherent Motion Imaging (NG-IVIM), an extension of the conventional apparent diffusion coefficient (<em>ADC</em>) model, for the head and neck. In the current study, we describe the first application in a group of patients with human papillomavirus (HPV)-positive and HPV-negative oropharyngeal squamous cell carcinoma. The aim of this study was to relate <em>ADC</em> and NG-IVIM DWI parameters to HPV status and clinical treatment response.</p></div><div><h3>Materials and methods</h3><p>Thirty-six patients (18 HPV-positive, 18 HPV-negative) were prospectively included. Presence of progressive disease was scored within one year. The mean pre-treatment <em>ADC</em> and NG-IVIM parameters in the gross tumor volume were compared between HPV-positive and HPV-negative patients. In HPV-negative patients, <em>ADC</em> and NG-IVIM parameters were compared between patients with and without progressive disease.</p></div><div><h3>Results</h3><p><em>ADC</em>, the NG-IVIM diffusion coefficient <em>D</em>, and perfusion fraction <em>f</em> were significantly higher, while pseudo-diffusion coefficient <em>D*</em> and kurtosis <em>K</em> were significantly lower in the HPV-negative compared to HPV-positive patients. In the HPV-negative group, a significantly lower <em>D</em> was found for patients with progressive disease compared to complete responders. No relation with <em>ADC</em> was observed.</p></div><div><h3>Conclusion</h3><p>The results of our single-center study suggest that <em>ADC</em> is related to HPV status, but not an independent response predictor. The NG-IVIM parameter <em>D,</em> however, was independently associated to response in the HPV-negative group. Noteworthy in the opposite direction as previously thought based on <em>ADC</em>.</p></div>","PeriodicalId":36850,"journal":{"name":"Physics and Imaging in Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405631624000447/pdfft?md5=21e7ad76975caaf833ab8dd40588c057&pid=1-s2.0-S2405631624000447-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics and Imaging in Radiation Oncology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405631624000447","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background and purpose

Diffusion-weighted imaging (DWI) is a promising technique for response assessment in head-and-neck cancer. Recently, we optimized Non-Gaussian Intravoxel Incoherent Motion Imaging (NG-IVIM), an extension of the conventional apparent diffusion coefficient (ADC) model, for the head and neck. In the current study, we describe the first application in a group of patients with human papillomavirus (HPV)-positive and HPV-negative oropharyngeal squamous cell carcinoma. The aim of this study was to relate ADC and NG-IVIM DWI parameters to HPV status and clinical treatment response.

Materials and methods

Thirty-six patients (18 HPV-positive, 18 HPV-negative) were prospectively included. Presence of progressive disease was scored within one year. The mean pre-treatment ADC and NG-IVIM parameters in the gross tumor volume were compared between HPV-positive and HPV-negative patients. In HPV-negative patients, ADC and NG-IVIM parameters were compared between patients with and without progressive disease.

Results

ADC, the NG-IVIM diffusion coefficient D, and perfusion fraction f were significantly higher, while pseudo-diffusion coefficient D* and kurtosis K were significantly lower in the HPV-negative compared to HPV-positive patients. In the HPV-negative group, a significantly lower D was found for patients with progressive disease compared to complete responders. No relation with ADC was observed.

Conclusion

The results of our single-center study suggest that ADC is related to HPV status, but not an independent response predictor. The NG-IVIM parameter D, however, was independently associated to response in the HPV-negative group. Noteworthy in the opposite direction as previously thought based on ADC.

口咽癌治疗前非高斯体内非相干运动扩散加权成像与人类乳头瘤病毒状态和反应的关系
背景和目的扩散加权成像(DWI)是一种用于头颈部癌症反应评估的有前途的技术。最近,我们优化了头颈部的非高斯体内相干运动成像(NG-IVIM),这是传统表观弥散系数(ADC)模型的扩展。在本研究中,我们描述了在一组人乳头瘤病毒(HPV)阳性和 HPV 阴性口咽鳞癌患者中的首次应用。这项研究的目的是将 ADC 和 NG-IVIM DWI 参数与 HPV 状态和临床治疗反应联系起来。对一年内是否出现进展性疾病进行评分。比较了HPV阳性和HPV阴性患者治疗前肿瘤总体积的平均ADC和NG-IVIM参数。结果 HPV 阴性患者的 ADC、NG-IVIM 弥散系数 D 和灌注分数 f 明显高于 HPV 阳性患者,而伪弥散系数 D* 和峰度 K 则明显低于 HPV 阳性患者。在HPV阴性组中,疾病进展患者的D明显低于完全应答者。结论我们的单中心研究结果表明,ADC与HPV状态有关,但不是独立的反应预测因子。然而,在HPV阴性组中,NG-IVIM参数D与反应有独立关系。值得注意的是,这与之前根据 ADC 得出的结论方向相反。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology Physics and Astronomy-Radiation
CiteScore
5.30
自引率
18.90%
发文量
93
审稿时长
6 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信