Circulation of yellow fever virus in Benin city, Edo state Nigeria

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-08 DOI:10.1016/j.biologicals.2024.101765

Joy Zitgwai Saidu , Nosakhare Odeh Eghafona

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Abstract

Yellow fever (YF) is one of the most acute viral hemorrhagic diseases of the 18th and 19th centuries, which continues to cause severe morbidity and mortality in Africa. After 21 years of no reported cases of yellow fever in Nigeria, till 2017 where a case was confirmed in Kwara State, also in November 2018,WHO was informed of a cluster of suspected yellow fever cases and deaths in Edo state, Nigeria. The study was among all age group attending health centres in Benin City, Edo state. A total of 280 blood samples were collected from consented febrile patients and were screened for antibodies to Zika virus using rapid diagnostic test (RDT) kits. Blood samples positive to Zika virus (IgM/IgG RDT), were subjected to molecular characterization. Using the flavividae family primers, six (6) samples where confirmed positive by Hemi-nested reverse transcription PCR (hnRT-PCR) sequencing. Nucleotide sequence blast revealed the sequenceswere similar to Yellow fever virus strains. Phylogenetic analysis revealed that the yellow fever virus sequences are closely related to the African strains. Despite the safe and effective yellow fever vaccine, yellow fever virus is seen to be in circulation, hence the need for continues mass vaccination.

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尼日利亚埃多州贝宁市黄热病病毒的流行情况

黄热病（YF）是 18 和 19 世纪最严重的病毒性出血性疾病之一，在非洲继续造成严重的发病率和死亡率。尼日利亚 21 年未报告黄热病病例，直到 2017 年才在夸拉州确诊一例病例，同样在 2018 年 11 月，世卫组织获悉尼日利亚埃多州出现疑似黄热病病例和死亡病例群。这项研究的对象是在埃多州贝宁市医疗中心就诊的所有年龄组人群。共收集了 280 份经同意的发热患者的血液样本，并使用快速诊断测试（RDT）试剂盒进行寨卡病毒抗体筛查。对寨卡病毒抗体（IgM/IgG RDT）呈阳性的血样进行了分子鉴定。使用黄花菜科引物，通过半嵌合反转录 PCR（hnRT-PCR）测序确认了六（6）份阳性样本。核苷酸序列爆炸显示，这些序列与黄热病病毒株相似。系统进化分析表明，黄热病病毒序列与非洲毒株密切相关。尽管黄热病疫苗安全有效，但黄热病病毒仍在流行，因此有必要继续进行大规模疫苗接种。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.