The Discovery of Diabetes Mellitus and its Three Hormones: Insulin, Proinsulin and Preproinsulin

Abstract

As the discoverer of Preproinsulin, I became interested in the other landmark insulin-related discoveries. It is a story of great science. Many Nobel prizes were given but, unfortunately, it is also a story of intrigue, deception and politics. In this article, I want to outline my own personal perspectives, opinions, and thoughts about how these discoveries came about.