Simultaneous estimation of ibuprofen, caffeine, and paracetamol in commercial products using a green reverse-phase HPTLC method

IF 3.8 4区工程技术 Q2 CHEMISTRY, MULTIDISCIPLINARY

Green Processing and Synthesis Pub Date : 2024-01-01 DOI:10.1515/gps-2023-0220

M. Alqarni, F. Shakeel, S. Alshehri, A. Foudah, T. M. Aljarba, Fatma Abdel Bar, P. Alam

{"title":"Simultaneous estimation of ibuprofen, caffeine, and paracetamol in commercial products using a green reverse-phase HPTLC method","authors":"M. Alqarni, F. Shakeel, S. Alshehri, A. Foudah, T. M. Aljarba, Fatma Abdel Bar, P. Alam","doi":"10.1515/gps-2023-0220","DOIUrl":null,"url":null,"abstract":"\n A fast, sensitive, and green reverse-phase “high-performance thin-layer chromatography” approach for the simultaneous estimation of ibuprofen (IBF), caffeine (CAF), and paracetamol (PCM) in marketed formulations was established and verified in this study. The binary combination of acetone and water (80:20 v/v) was used as the green eluent system. The current method’s greenness was predicted using four different approaches, namely National Environmental Method Index, Analytical Eco-Score (89), ChlorTox (1.08 g), and the Analytical GREENness (83) approaches, which demonstrated an outstanding greener profile. The present approach was linear in the range of 25–800 ng·band−1 for the simultaneous estimation of IBF, CAF, and PCM. In addition, the current method was accurate (% recoveries = 100 ± 2), precise (%CV < 2%), robust (%CV < 2), sensitive (LOD = 1.13–2.71 ng·band−1 and LOQ = 3.39–8.10 ng·band−1), and green. The amount of IBF, CAF, and PCM in commercial tablets was determined to be 99.51%, 98.25%, and 100.64%, respectively. The present method for the simultaneous determination of IBF, CAF, and PCM in marketed tablets is supported by these data. The findings of this study suggested that the current approach may be consistently applied to analyze IBF, CAF, and PCM in marketed tablets.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":3.8000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Processing and Synthesis","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1515/gps-2023-0220","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

A fast, sensitive, and green reverse-phase “high-performance thin-layer chromatography” approach for the simultaneous estimation of ibuprofen (IBF), caffeine (CAF), and paracetamol (PCM) in marketed formulations was established and verified in this study. The binary combination of acetone and water (80:20 v/v) was used as the green eluent system. The current method’s greenness was predicted using four different approaches, namely National Environmental Method Index, Analytical Eco-Score (89), ChlorTox (1.08 g), and the Analytical GREENness (83) approaches, which demonstrated an outstanding greener profile. The present approach was linear in the range of 25–800 ng·band−1 for the simultaneous estimation of IBF, CAF, and PCM. In addition, the current method was accurate (% recoveries = 100 ± 2), precise (%CV < 2%), robust (%CV < 2), sensitive (LOD = 1.13–2.71 ng·band−1 and LOQ = 3.39–8.10 ng·band−1), and green. The amount of IBF, CAF, and PCM in commercial tablets was determined to be 99.51%, 98.25%, and 100.64%, respectively. The present method for the simultaneous determination of IBF, CAF, and PCM in marketed tablets is supported by these data. The findings of this study suggested that the current approach may be consistently applied to analyze IBF, CAF, and PCM in marketed tablets.

查看原文本刊更多论文

采用绿色反相 HPTLC 法同时估算商业产品中的布洛芬、咖啡因和扑热息痛

本研究建立并验证了一种快速、灵敏、绿色的反相 "高效薄层色谱 "方法，用于同时测定市售制剂中的布洛芬（IBF）、咖啡因（CAF）和扑热息痛（PCM）。采用丙酮和水（80:20 v/v）的二元组合作为绿色洗脱体系。使用四种不同的方法，即国家环境方法指数法、分析生态分数法（89）、氯毒法（1.08 g）和分析绿色度法（83）预测了当前方法的绿色程度，结果表明该方法具有突出的绿色特性。本方法在 25-800 纳克-带-1 范围内线性良好，可同时估计 IBF、CAF 和 PCM。此外，该方法准确（回收率 = 100 ± 2%）、精确（%CV < 2%）、稳健（%CV < 2%）、灵敏（LOD = 1.13-2.71 ng-band-1 和 LOQ = 3.39-8.10 ng-band-1）且绿色环保。经测定，商品片剂中 IBF、CAF 和 PCM 的含量分别为 99.51%、98.25% 和 100.64%。这些数据为本方法同时测定市售片剂中 IBF、CAF 和 PCM 的含量提供了支持。研究结果表明，目前的方法可用于分析市售片剂中的 IBF、CAF 和 PCM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Green Processing and Synthesis CHEMISTRY, MULTIDISCIPLINARY-ENGINEERING, CHEMICAL

CiteScore

6.70

自引率

9.30%

发文量

审稿时长

7 weeks

期刊介绍： Green Processing and Synthesis is a bimonthly, peer-reviewed journal that provides up-to-date research both on fundamental as well as applied aspects of innovative green process development and chemical synthesis, giving an appropriate share to industrial views. The contributions are cutting edge, high-impact, authoritative, and provide both pros and cons of potential technologies. Green Processing and Synthesis provides a platform for scientists and engineers, especially chemists and chemical engineers, but is also open for interdisciplinary research from other areas such as physics, materials science, or catalysis.

文献相关原料

公司名称	产品信息	采购帮参考价格