Function of Circular RNAs (circRNAs) in Colorectal Cancer

Abstract

Circular RNAs (circRNAs) are a class of non-coding RNAs formed by covalently closed loops through backsplicing. From previous studies, RNA was found to be involved in the development and formation of colorectal cancer. Emphasis on the true function of circRNAs in colorectal cancer, by focusing on the application of biogenesis, disease treatment and as a biomarker is able to develop cancer therapy with round RNA as a target. Cancer is a chronic disease that contributes to high mortality worldwide. Colorectal cancer is the most common cancer in the world and in Malaysia in general. The incidence and mortality rates of colorectal cancer worldwide show a drastic and alarming increase. Colorectal cancer occurs due to mutations from certain genes involved in proliferation regulation, cell survival and cell death. This article aims to discuss the role and importance of round RNA in colorectal cancer. By identifying the true function of circRNAs, it can help us to develop our understanding of the biological role of real round RNA molecules in colorectal cancer.