An Overview of Various Approaches for Brain Targeted Drug Delivery System

Q4 Medicine

International Journal of Nutrition, Pharmacology, Neurological Diseases Pub Date : 2024-01-01 DOI:10.4103/ijnpnd.ijnpnd_72_23

R. Parthiban, M. M., Mullaicharam Bhupathyraaj, S. Sridhar, J. Shareef, Sabin Thomas, Ashok Kumar Janakiraman

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Abstract

The blood-brain barrier (BBB) protects the central nervous system, one of the body’s most fragile microenvironments, by controlling its homeostasis. The BBB is a very complex system that strictly restricts the transport of ions from the blood to the brain of a confined amount of tiny molecules and a much lower number of large molecules, defending the brain from diseases and injuries. However, the BBB severely inhibits drug transport to the brain, hindering the treatment of various neurological problems. As a result, numerous techniques are under development to improve drug delivery across the BBB. This review summarizes the anatomical and physiological characteristics of the barriers and the current drug delivery strategies for the brain. Although these methods provide many fascinating possibilities for targeting and brain delivery, only a few have progressed to the point where they can be used safely and effectively in humans. In addition, concerted efforts using a variety of other methodologies will enable the translation of preclinical findings into tangible clinical applications in the targeted delivery of drugs.

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脑靶向给药系统的各种方法概述

中枢神经系统是人体最脆弱的微环境之一，血脑屏障（BBB）通过控制中枢神经系统的平衡来保护中枢神经系统。血脑屏障是一个非常复杂的系统，它严格限制离子从血液向大脑的运输，其中包括数量有限的微小分子和数量少得多的大分子，从而保护大脑免受疾病和伤害。然而，BBB 严重抑制了药物向大脑的转运，阻碍了各种神经系统疾病的治疗。因此，目前正在开发多种技术，以改善通过 BBB 的药物输送。本综述总结了屏障的解剖学和生理学特征以及目前的脑部给药策略。尽管这些方法为靶向和脑部给药提供了许多令人着迷的可能性，但只有少数几种方法已经发展到可以安全有效地用于人体的地步。此外，使用其他各种方法的共同努力将使临床前研究成果转化为靶向给药的实际临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nutrition, Pharmacology, Neurological Diseases Medicine-Pharmacology (medical)

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The International Journal of Nutrition, Pharmacology, Neurological Diseases (IJNPND) is an international, open access, peer reviewed journal which covers all fields related to nutrition, pharmacology, neurological diseases. IJNPND was started by Dr. Mohamed Essa based on his personal interest in Science in 2009. This journal doesn’t link with any society or any association. The co-editor-in chiefs of IJNPND (Prof. Gilles J. Guillemin, Dr. Abdur Rahman and Prof. Ross grant) and editorial board members are well known figures in the fields of Nutrition, pharmacology, and neuroscience. First, the journal was started as two issues per year, then it was changed into 3 issues per year and since 2013, it publishes 4 issues per year till now. This shows the slow and steady growth of this journal. To support the reviewers and editorial board members, IJNPND offers awards to the people who does more reviews within one year. The International Journal of Nutrition, Pharmacology, Neurological Diseases (IJNPND) is published Quarterly. IJNPND has three main sections, such as nutrition, pharmacology, and neurological diseases. IJNPND publishes Research Papers, Review Articles, Commentaries, case reports, brief communications and Correspondence in all three sections. Reviews and Commentaries are normally commissioned by the journal, but consideration will be given to unsolicited contributions. International Journal of Nutrition, Pharmacology, Neurological Diseases is included in the UGC-India Approved list of journals.