BIGINELLI REACTION: COMPARATIVE STUDY OF FRUIT JUICES, OPTIMIZATION STRATEGIES, IN-SILICO ANALYSIS AND PHARMACOLOGICAL ACTIVITY

M. Hudgi, S. Santh, A. Awasthi, B. Mantripragada, D. Pingili
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Abstract

This research article explores the influence of fruit juices on the efficiency of the biginelli reaction, a versatile multicomponent synthesis for diverse dihydropyrimidinones. A comparative analysis of fruit juices as green reaction media assessed their impact on reaction rates, yields, and selectivity. Biginelli reactions were carried out in fruit juices using equimolar mixture of thiourea /urea, ethyl acetoacetate and aromatic aldehyde under microwave irradiation. The reaction progressed within minutes, monitored by TLC
biginelli 反应:果汁比较研究、优化策略、硅内分析和药理活性
这篇研究文章探讨了果汁对 biginelli 反应效率的影响,该反应是一种多功能多组分合成法,可合成多种二氢嘧啶酮。通过对果汁作为绿色反应介质的比较分析,评估了它们对反应速率、产量和选择性的影响。在微波辐照下,使用硫脲/尿素、乙酰乙酸乙酯和芳香醛的等摩尔混合物在果汁中进行了比吉内利反应。反应在几分钟内完成,并通过 TLC
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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