In Vitro Evaluation of Alpha Amylase and Alpha Glucosidase Inhibitory Activity of Kamadhenu Ark extracts of Climate Smart Crop Millets

Q3 Pharmacology, Toxicology and Pharmaceutics

Research Journal of Pharmacy and Technology Pub Date : 2024-01-19 DOI:10.52711/0974-360x.2024.00013

Venkata Lakshmi J, Ch. M. Kumari Chitturi, C. A. Rao

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引用次数: 0

Abstract

Diabetes Mellitus is characterized by abnormal Metabolism of glucose. The maintenance of glucose levels in blood without any side effects is still challenging in the medication of this disease. Various medical approaches like Allopathy, Homeopathy, Ayurveda, Unani etc are striving a lot for success in this field of medication. Present study is aimed to evaluate the Antidiabetic activity of Millets in combination with Kamadhenu Ark as solvent for the probable alpha Amylase and alpha Glucosidase inhibitory activities to reduce hyperglycemia. The Millets namely Paspalum scrobiculatum, Panicum miliaceum, Panicum sumatrense were selected for the study. The Kamadhenu Ark Extracts were prepared by Maceration method. The extracts were used for the estimation of alpha amylase and alpha-glucosidase inhibition activity. Extract of Panicum miliaceum exhibited highest α amylase and α glucosidase inhibitory potential with IC50 values of 0.239 and 1.526 mg/ml, respectively, which was comparable with acarbose (0.258 and 1.985 mg/ml). Extracts of Paspalum scrobiculatum and Panicum sumatrense have shown low activity. Present study paves a new path revealing the effective inhibition of α amylase and α glucosidase by Kamadhenu Ark extract of Panicum miliaceum (Proso Millet KPM).

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体外评价卡玛德努方舟提取物对气候智能型作物黍稷的α-淀粉酶和α-葡萄糖苷酶的抑制活性

糖尿病的特点是葡萄糖代谢异常。如何在不产生任何副作用的情况下维持血液中的葡萄糖水平，仍然是治疗这种疾病的一大挑战。异体疗法、顺势疗法、阿育吠陀、尤那尼等各种医疗方法都在努力争取在这一领域取得成功。本研究旨在评估黍米与卡玛德努方舟（Kamadhenu Ark）结合作为溶剂的抗糖尿病活性，其可能具有抑制α-淀粉酶和α-葡萄糖苷酶以降低高血糖的活性。研究选择了稗子（Paspalum scrobiculatum、Panicum miliaceum、Panicum sumatrense）。卡玛德努方舟提取物采用浸渍法制备。这些提取物用于估算α-淀粉酶和α-葡萄糖苷酶的抑制活性。稗草提取物对α-淀粉酶和α-葡萄糖苷酶的抑制潜力最高，IC50 值分别为 0.239 和 1.526 mg/ml，与阿卡波糖（0.258 和 1.985 mg/ml）相当。Paspalum scrobiculatum 和 Panicum sumatrense 的提取物显示出较低的活性。本研究开辟了一条新途径，揭示了 Kamadhenu Ark 小麦提取物对α 淀粉酶和α 葡萄糖苷酶的有效抑制作用。

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来源期刊

Research Journal of Pharmacy and Technology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.