Natural Products Regulate the P38MAPK Signaling Pathway: A Promising Strategy in the Prevention and Treatment of Alzheimer’s Disease

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2024-01-22 DOI:10.37290/ctnr2641-452x.22:509-518

Yue Zhu, Mengyuan Qiao, Jinxin Chen, Manru Xu, Wenbin Wu

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引用次数: 0

Abstract

Alzheimer’s disease is a common neurodegenerative condition that severely affects the quality of life of patients and their families, resulting in a substantial societal burden. In the pathogenesis of Alzheimer’s disease, the p38 mitogen-activated protein kinase pathway is closely associated with neuroinflammation, apoptosis, synaptic plasticity, amyloid beta deposition, and aberrant tau phosphorylation. Natural products have a high potential for therapeutic modulation of the P38 MAPK pathway. We searched PubMed, EMBASE, Medline, and Web of Science, utilizing the keywords “Alzheimer’s disease,” “neurodegenerative diseases,” “MAPK,” and “P38MAPK” and “natural products” to identify natural products that can be used to treat Alzheimer’s disease by modulating the P38MAPK pathway. Various natural products were found to act on p38 MAPK, including saponins, flavonoids, alkaloids, acids, terpenoids, and glycosides. All these active agents can treat Alzheimer’s disease through their interactions with p38 MAPK. This study aimed to examine the use of natural products to intervene in Alzheimer’s disease and regulate the p38 MAPK pathway to provide potential ideas for further drug research and development.

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天然产品可调节 P38MAPK 信号通路：预防和治疗阿尔茨海默病的有效策略

阿尔茨海默病是一种常见的神经退行性疾病，严重影响患者及其家人的生活质量，造成巨大的社会负担。在阿尔茨海默病的发病机制中，p38 丝裂原活化蛋白激酶通路与神经炎症、细胞凋亡、突触可塑性、淀粉样蛋白 beta 沉积和 tau 磷酸化异常密切相关。天然产品在治疗调节 P38 MAPK 通路方面具有很大的潜力。我们以 "阿尔茨海默病"、"神经退行性疾病"、"MAPK"、"P38MAPK "和 "天然产品 "为关键词，对 PubMed、EMBASE、Medline 和 Web of Science 进行了检索，以确定可用于通过调节 P38MAPK 通路治疗阿尔茨海默病的天然产品。研究发现，多种天然产品可作用于 P38MAPK，包括皂苷、黄酮类、生物碱、酸类、萜类和苷类。所有这些活性物质都能通过与 p38 MAPK 的相互作用治疗阿尔茨海默病。本研究旨在探讨利用天然产物干预阿尔茨海默病并调节 p38 MAPK 通路，从而为进一步的药物研究和开发提供潜在的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.

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