Hyperuricemia and hypertension in working-age people: results of a population study

Q3 Social Sciences

Cardiovascular Therapy and Prevention Pub Date : 2024-01-28 DOI:10.15829/1728-8800-2023-3783

S. Shalnova, A. Imaeva, V. Kutsenko, Y. Balanova, A. Kapustina, R. Shepel, O. Drapkina

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引用次数: 0

Abstract

Aim. To study the prevalence of hyperuricemia (HU) and gout depending on hypertension (HTN), as well as to evaluate their associations with mortality in the Russian population.Material and methods. The analysis included data obtained in two cross-sectional studies — ESSE-RF and ESSE-RF2. All study participants were surveyed using a modular designed questionnaire. Serum uric acid (UA) was determined using the uricase method. HU corresponded to a UA >420 µmol/l in men and >360 µmol/l in women. HU without gout was considered asymptomatic HU in the present study. Associations with endpoints were assessed using Cox proportional hazards models with associated hazard ratios.Results. The average prevalence of HU was 18,2%. HU, as expected, predominates among the male cohort — 22,6% vs 15,7%, respectively. The prevalence of asymptomatic HU was 4,4% higher among men compared to women. The prevalence of gout increased with age and averaged 2,6% in the entire population. A high content of UA was revealed in men in the absence of hypertension. The prevalence of HU in women with HTN was 3 times higher than in participants without hypertension. In the male cohort, in the group of hypertension without HU, all-cause and cardiovascular mortality significantly increases, and in the group with hypertension and HU, only all-cause mortality increases. In women, the cardiovascular death risk increased in HTN — hazard ratio 3,98 (95% confidence interval 1,86-8,52). At the same time, in women with HTN and HU, all-cause and cardiovascular death risk increased by 66% and 6,7 times, respectively.Conclusion. Every fifth study participant was diagnosed with HU. The prevalence of HU in hypertensive men was approximately 1,5 times higher than without hypertension. In women with HTN, HU was detected three times more often than without HTN, which may indicate a more pronounced relationship between HTN and HU in women. HU can worsen the HTN prognosis. Thus, monitoring and timely correction of UA levels in hypertensive patients become necessary to improve the prognosis.

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工作年龄人群的高尿酸血症和高血压：一项人口研究的结果

目的研究高尿酸血症（HU）和痛风的发病率与高血压（HTN）的关系，并评估它们与俄罗斯人口死亡率的关系。分析包括两项横断面研究--ESSE-RF 和 ESSE-RF2 获得的数据。所有研究参与者均接受了模块化设计的问卷调查。使用尿酸酶法测定血清尿酸（UA）。男性尿酸大于 420 µmol/l，女性尿酸大于 360 µmol/l，即为 HU。在本研究中，无痛风的 HU 被视为无症状 HU。研究采用Cox比例危险模型评估了HU与终点的相关性及相关危险比。HU的平均患病率为18.2%。正如预期的那样，HU 主要发生在男性群体中，分别为 22.6% 和 15.7%。男性无症状HU的患病率比女性高4.4%。痛风的发病率随着年龄的增长而增加，在整个人群中平均为 2.6%。在没有高血压的情况下，男性的尿酸含量较高。患有高血压的女性的 HU 患病率是无高血压者的 3 倍。在男性人群中，无高血压组的全因死亡率和心血管死亡率显著增加，而有高血压和高血压组的全因死亡率仅增加。女性高血压患者的心血管死亡风险增加--危险比为 3.98（95% 置信区间为 1.86-8.52）。同时，在患有高血压和心血管疾病的女性中，全因死亡和心血管死亡风险分别增加了 66% 和 6.7 倍。每五名研究参与者中就有一人被确诊患有高血压。高血压男性的 HU 患病率约为无高血压男性的 1.5 倍。在患有高血压的女性中，HU 的检出率是未患高血压女性的三倍，这可能表明女性高血压与 HU 之间的关系更为明显。HU会加重高血压的预后。因此，有必要对高血压患者的尿酸水平进行监测并及时纠正，以改善预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Therapy and Prevention Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.70

自引率

0.00%

发文量

155

审稿时长

6-12 weeks

期刊介绍： The most important objectives of the journal are: the generalization of scientific and practical achievements in the field of cardiology, increasing scientific and practical skills of cardiologists. The scientific concept of publication does the publication of modern achievements in the field of epidemiology, prevention and treatment of cardiovascular diseases, the results of research, national and international clinical trials. For publication in the journal are invited both domestic and foreign scientists and clinicians working in the field of cardiology, as well as doctors of other specialties. The magazine covers various issues in cardiology and related specialties. Each issue is prepared by Executive editor of the issue, a respected specialist in the field of epidemiology, prevention and treatment of cardiovascular diseases. The main focus of the publication — scientific articles on original research, the pharmacotherapy of cardiovascular disease, new diagnostic methods. All members of the group of authors should meet all four criteria of authorship set forth in the ICMJE recommendations: 1) concept and design development or data analysis and interpretation, and 2) manuscript justification or verification of critical intellectual content, and 3) final approval for publication of the manuscript, and 4) consent to be responsible for all aspects of the work, and assume that issues relating to the thoroughness and diligent execution of any part of the study submitted are duly investigated and resolved. Great importance the editors attached to the preparation of scientific papers by groups of authors at a high level, literacy, authors, and their ownership information, availability of research results not only to colleagues in Russia, but also abroad.