Immunohistochemical Study of Female Breast Cancer in Varna, Bulgaria

Abstract

An immunohistochemical study of 128 female breast cancer patients in Varna is performed. The expression of estrogen and progesterone receptors, human epidermal growth factor receptor 2 (HER2) and proliferation marker protein Ki-67 in terms of histological and molecular types and differentiation grade is assessed. Ductal carcinoma and luminal B HER2(+) prevail. The discrepancies between immunohistochemical positivity and negativity of single biomarkers are outlined.