Grape Seed Extract Affects Body Weight, Liver Weight and Relative Tissue Weight Index in Aluminium Chloride Treated Rats

Sadia Iqbal, Muhammad Suhail, Ahmad Haris Suhail, Faiza Rauf, Faiza Shafqat, Maria Illyas
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Abstract

Introduction: Grape seed extract (vitis vinifera) contains antioxidant compounds with ability to prevent aluminium chloride induced hepatotoxicity. Aims & Objectives: To study the effects of grape seed extract on body weight, liver weight and relative tissue weight index in aluminium chloride treated rats. Place and Duration of Study: This experimental study study was conducted at the Animal House of Post Graduate Medical Institute, Lahore. Duration of study was February 2017 to February 2018. Material & Methods: 24 adult, healthy albino rats (male) were divided in to three groups. Group A was given distilled water by gavage (1ml/day), Group B was given aluminium chloride (34mg/kg body weight) and group C was given aluminium chloride plus grape seed extract (34mg/kg and 200 mg/kg body weight) by gavage. Whole treatment continued for 42 days. Statistical Package for Social Sciences (SPSS) version 21 was used for entering and analyzing data.p value of ? 0.05 was considered significant. Results: A significant difference in body weights of Group B and C rats was noted at the end of the study. Mean liver weight was significantly reduced in aluminium treated group and near normal restoration of liver weight was seen in group C receiving grape seed extract. Conclusion: Excessive aluminium chloride exposure led to a reduction in body weight, and liver weight. Grape seed extract being an antioxidant improved these effects.
葡萄籽提取物影响氯化铝处理大鼠的体重、肝脏重量和相对组织重量指数
简介葡萄籽提取物(葡萄)含有抗氧化化合物,能够预防氯化铝诱导的肝毒性:研究葡萄籽提取物对氯化铝处理大鼠体重、肝脏重量和相对组织重量指数的影响:本实验研究在拉合尔医学研究生院动物房进行。研究时间为 2017 年 2 月至 2018 年 2 月。材料与方法:将 24 只成年健康白化大鼠(雄性)分为三组。A 组灌胃蒸馏水(1 毫升/天),B 组灌胃氯化铝(34 毫克/千克体重),C 组灌胃氯化铝加葡萄籽提取物(34 毫克/千克和 200 毫克/千克体重)。整个治疗持续 42 天。使用 21 版社会科学统计软件包(SPSS)输入和分析数据:研究结束时,B 组和 C 组大鼠的体重有明显差异。结果:研究结束时,B 组和 C 组大鼠的体重有明显差异,铝处理组大鼠的平均肝脏重量明显减少,而接受葡萄籽提取物的 C 组大鼠的肝脏重量恢复接近正常:结论:过量接触氯化铝会导致体重和肝脏重量下降。葡萄籽提取物是一种抗氧化剂,可改善这些影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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