Relationship between Leprosy Suspicion Questionnaire with IgM anti-PGL-1 antibody levels in household contacts of leprosy

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Mutia Fadhila Sy, R. Lubis, Kristina Nadeak
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引用次数: 0

Abstract

Introduction: Leprosy is a chronic granulomatous disease affecting mainly the skin and peripheral nerves caused by the obligate intracellular pathogen Mycobacterium leprae. This study aimed to determine the relationship between Leprosy Suspicion Questionnaire (LSQ) and anti-PGL-1 IgM antibody levels in household contacts of leprosy patients. Methods: This research was an observational analytical study with a cross-sectional design. The sample consisted of 30 subjects who were household contacts of leprosy patients. Anti-PGL-1 IgM antibody levels were examined using the ELISA method at the Cito Laboratory, Yogyakarta. Results: Regarding demographic characteristics, there were 18 female subjects (60%) and 12 male subjects (40%). LSQ+ results were found in 22 (73.3%) subjects, while LSQ- results were found in 8 (26.7%) subjects. The results of the anti-PGL-1 IgM examination were classified into three categories, namely seronegative (<605 U/ mL) totaling 25 people (83.3%), low titer seropositivity (605–1000 U/mL) totaling four people (13.3 %), and high titer seropositivity (>1000 U/mL) was one person (3.3%). The mean value of IgM anti-PGL-1 was 383.63 U/mL, with the lowest value being 0 and the highest being 1593 U/mL. Using Fischer's Exact showed no relationship between LSQ and IgM Anti-PGL-1 (p=0.287). Conclusions: No relationship was found between LSQ and anti-PGL-1 IgM antibody levels in household contacts of leprosy patients. The results of the LSQ answers correlated with anti-PGL-1 IgM antibodies found in only five subjects.
麻风病疑似症状问卷与麻风病家庭接触者 IgM 抗PGL-1 抗体水平之间的关系
简介麻风病是一种主要影响皮肤和周围神经的慢性肉芽肿性疾病,由细胞内强制性病原体麻风分枝杆菌引起。本研究旨在确定麻风病人家庭接触者的麻风病疑似症状问卷(LSQ)与抗-PGL-1 IgM抗体水平之间的关系:本研究是一项横断面观察分析研究。样本包括 30 名麻风病人的家庭接触者。在日惹的Cito实验室使用ELISA方法检测了抗PGL-1 IgM抗体水平:在人口统计学特征方面,有 18 名女性受试者(60%)和 12 名男性受试者(40%)。22名受试者(73.3%)的LSQ结果为+,8名受试者(26.7%)的LSQ结果为-。抗PGL-1 IgM 检查结果分为三类,即血清阴性(1000 U/mL)1 人(3.3%)。抗PGL-1 IgM 的平均值为 383.63 U/mL,最低值为 0,最高值为 1593 U/mL。费舍尔精确检验显示 LSQ 与 IgM 抗PGL-1 之间没有关系(P=0.287):结论:麻风病人家庭接触者的 LSQ 与抗-PGL-1 IgM 抗体水平之间没有关系。LSQ答案的结果与仅在5名受试者中发现的抗PGL-1 IgM抗体相关。
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来源期刊
Bali Medical Journal
Bali Medical Journal MEDICINE, GENERAL & INTERNAL-
自引率
50.00%
发文量
8
审稿时长
3 weeks
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