{"title":"Uncommon Metachronicity: Breast and Endometrial Carcinomas in a Young Woman with No Familial Cancer History - A Case Report","authors":"Naina Kumar, S. Palo, Aadil Sinha, M. Mangla","doi":"10.2174/0115733947283731240215102133","DOIUrl":null,"url":null,"abstract":"\n\nWorldwide, breast and endometrial carcinomas are the two most common\ncancers of women, but their coexistence in a woman <40 years of age is a rare event. The risk of developing\na new second primary cancer is higher in cancer survivors compared to those without a history\nof cancer. The exact pathogenesis of two different primary malignancies is not clear. Still, the\ncoexistence of breast and endometrial carcinoma may be due to germline mutations of p53, BRCA 1,\nand BRCA 2 genes, environmental, hereditary, and immune-mediated factors.\n\n\n\nThe present case report briefs the finding of a 37-year-old woman who presented\nto the Gynecological outpatient department with complaints of abnormal uterine bleeding and a solid\nirregular lump in the upper outer quadrant of the right breast and the right axilla. She had a history of\nmodified radical mastectomy for left breast ductal carcinoma five years back. She was diagnosed as a\ncase of metachronous endometrial carcinoma (stage IA) with a recurrence of invasive ductal carcinoma\nin the right breast with metastasis to the right axillary lymph node.\n\n\n\nThe metachronous development of breast and endometrial carcinoma in young women\nis relatively rare. In young patients <40 years of age with gynecological or breast carcinoma, a thorough\nwork-up, including genetic testing and follow-up, should be done for early diagnosis of metachronous\nor synchronous primary malignancies of other organs.\n","PeriodicalId":503819,"journal":{"name":"Current Cancer Therapy Reviews","volume":"52 5","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Cancer Therapy Reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0115733947283731240215102133","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Worldwide, breast and endometrial carcinomas are the two most common
cancers of women, but their coexistence in a woman <40 years of age is a rare event. The risk of developing
a new second primary cancer is higher in cancer survivors compared to those without a history
of cancer. The exact pathogenesis of two different primary malignancies is not clear. Still, the
coexistence of breast and endometrial carcinoma may be due to germline mutations of p53, BRCA 1,
and BRCA 2 genes, environmental, hereditary, and immune-mediated factors.
The present case report briefs the finding of a 37-year-old woman who presented
to the Gynecological outpatient department with complaints of abnormal uterine bleeding and a solid
irregular lump in the upper outer quadrant of the right breast and the right axilla. She had a history of
modified radical mastectomy for left breast ductal carcinoma five years back. She was diagnosed as a
case of metachronous endometrial carcinoma (stage IA) with a recurrence of invasive ductal carcinoma
in the right breast with metastasis to the right axillary lymph node.
The metachronous development of breast and endometrial carcinoma in young women
is relatively rare. In young patients <40 years of age with gynecological or breast carcinoma, a thorough
work-up, including genetic testing and follow-up, should be done for early diagnosis of metachronous
or synchronous primary malignancies of other organs.