Advances in neuroprotective therapy for acute ischemic stroke

Yang Yang, Dandan Guo, Yiming Liu, Yi Li
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Abstract

Acute ischemic stroke (AIS) is the leading cause of disability worldwide, and recanalization therapy is significant in the hyperacute phase of AIS. However, reperfusion injury and hemorrhagic transformation after recanalization predict poor prognosis of AIS. How to minimize reperfusion injury and hemorrhagic transformation, which greatly improves the prognosis of vascular recanalization, is becoming a hot topic in AIS research and an urgent problem to be solved. A wealth of neuroprotective drug studies is now available, while some of the neuroprotectants have met with failure in human studies. It is discussed in this review about the progress in neuroprotective therapy for AIS based on understanding the pathophysiologic mechanisms of reperfusion injury and hemorrhagic transformation, as well as challenges in exploring new neuroprotectants.
急性缺血性脑卒中神经保护疗法的进展
急性缺血性卒中(AIS)是全球致残的主要原因,而再通血管疗法在 AIS 的超急性期意义重大。然而,再通后的再灌注损伤和出血转化预示着 AIS 的不良预后。如何最大限度地减少再灌注损伤和出血转化,从而大大改善血管再通的预后,正成为AIS研究的热点和亟待解决的问题。目前已有大量的神经保护药物研究,而一些神经保护剂在人体研究中却遭遇失败。本综述将讨论在了解再灌注损伤和出血转化的病理生理机制的基础上,AIS 神经保护疗法所取得的进展,以及探索新的神经保护剂所面临的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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