Inmunoexpresión de SOX9 en tumores primarios de carcinoma colorrectal con metástasis a ganglios linfáticos

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY

Revista de Gastroenterologia de Mexico Pub Date : 2024-07-01 DOI:10.1016/j.rgmx.2024.01.004

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引用次数: 0

Abstract

Introduction and aims

Colorectal cancer is the most frequent malignant tumor of the digestive system. Its pathogeny is complex and involves the APC/β-catenin sequence. Lymph node metastases are a significant indicator for determining treatment and are a prognostic factor. SOX9 overexpression is related to oncogenic qualities and the capacity for metastasis. Our aim was to analyze SOX9 immunoexpression in primary colorectal cancer and lymph node metastasis status.

Material and methods

Seventy-nine available cases were divided into the group with lymph node metastasis (n = 38) and the group without lymph node metastasis (n = 41), evaluating their SOX9 expression. The IBM SPSS version 27 program in Spanish was utilized to carry out the statistical analysis, obtaining measures of central tendency, the kappa index, standard deviation, Wilcoxon Mann-Whitney nonparametric measurements, Spearman's correlation coefficient, and chi-square test and Student's t test values. SOX9 immunoexpression was evaluated through the mean-based H-score, with high immunoexpression as a score ≥ 145 and low immunoexpression as a score ≤ 144.

Results

A p = 0.73 was obtained that was not statistically significant, regarding the relation of SOX9 expression in primary colorectal cancer to lymph node metastasis.

Conclusions

The absence or presence of lymph node metastasis was independent from SOX9 immunoexpression in primary colorectal cancer. However, due to the limited size of the population analyzed, further research is needed.

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伴有淋巴结转移的原发性结直肠癌肿瘤中的 SOX9 免疫表达

引言和目的结直肠癌是消化系统中最常见的恶性肿瘤。其病因复杂，涉及 APC/β-catenin 序列。淋巴结转移是决定治疗的一个重要指标，也是一个预后因素。SOX9的过表达与致癌特性和转移能力有关。材料和方法将79例病例分为有淋巴结转移组（38例）和无淋巴结转移组（41例），评估其SOX9的表达情况。统计分析采用西班牙文 IBM SPSS 27 版程序进行，获得了中心倾向测量、卡帕指数、标准差、Wilcoxon Mann-Whitney 非参数测量、Spearman 相关系数、卡方检验和学生 t 检验值。结果关于原发性结直肠癌中 SOX9 表达与淋巴结转移的关系，P=0.73，无统计学意义。然而，由于分析的人群规模有限，还需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista de Gastroenterologia de Mexico GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

1.60

自引率

12.50%

发文量

102

审稿时长

12 weeks

期刊介绍： La Revista de Gastroenterología de México es el órgano oficial de la Asociación Mexicana de Gastroenterología. Sus espacios están abiertos a los miembros de la Asociación como a todo miembro de la comunidad médica que manifieste interés por utilizar este foro para publicar sus trabajos, cumpliendo con las políticas editoriales que a continuación se mencionan. El objetivo principal de la Revista de Gastroenterología de México, es publicar trabajos originales del amplio campo de la gastroenterología, así como proporcionar información actualizada y relevante para el área de la especialidad y áreas afines. Los trabajos científicos incluyen las áreas de Gastroenterología clínica, endoscópica, quirúrgica y pediátrica.