Convergencia clínica: un caso excepcional de sarcoidosis y tuberculosis con múltiples manifestaciones orgánicas. Reporte de caso

Q3 Health Professions

Revista Colombiana de Reumatologia Pub Date : 2025-01-01 DOI:10.1016/j.rcreu.2024.01.004

Néstor Correa-González , María Claudia Díaz , Keyla Jemihah Triana Ángel , María Daniela Polania , Natalia Remolina Murillo , Pilar Alarcón Robles

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引用次数: 0

Abstract

Introduction

The diagnosis of sarcoidosis is challenging, especially if the patient has concomitant infectious symptoms. Furthermore, the overlap of immune-mediated and infectious pathologies is not uncommon.

Objective

To report a rare case of association between tuberculosis and sarcoidosis.

Materials and methods

Description of the clinical characteristics of a patient who presented with sarcoidosis superimposed on tuberculosis.

Results

The case of a 29-year-old man with ocular, cutaneous, and systemic symptoms is described. Uveitis and chronic non-caseating granulomatous findings were diagnosed in the skin, lungs, and lymph nodes. Suspicion of tuberculosis led to positive molecular biology tests only in the lymph node biopsy. An overlap of sarcoidosis and tuberculosis was determined, and combined treatment with glucocorticoids and anti-tuberculosis agents was initiated, resulting in improvement of the patient.

Conclusions

Sarcoidosis and tuberculosis share characteristics from their aetiology to clinical manifestations, posing a challenge in clinical differentiation. Cases have been documented where both diseases overlap in the same patient.

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临床表现趋同：肉样瘤病和结核病伴多器官表现的特殊病例。病例报告

结节病的诊断是具有挑战性的，特别是如果患者有伴随的感染症状。此外，免疫介导和感染性病理的重叠并不罕见。目的报告一例罕见的结核与结节病合并的病例。材料与方法对一例结节病合并肺结核患者的临床特征进行描述。结果一例29岁男性，眼部、皮肤和全身症状被描述。葡萄膜炎和慢性非干酪化肉芽肿的发现被诊断为皮肤，肺部和淋巴结。怀疑为肺结核，仅在淋巴结活检中分子生物学检测呈阳性。结节病与结核有重叠，开始联合糖皮质激素和抗结核药物治疗，使患者病情好转。结论结节病与结核在病因、临床表现等方面具有共同特点，临床鉴别具有一定难度。有记录的病例中，这两种疾病在同一患者重叠。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Colombiana de Reumatologia Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Colombian Journal of Rheumatology (Revista Colombiana de Reumatología) is the official organ of the Colombian Association of Rheumatology (Asociación Colombiana de Reumatología) and the Central American, Caribbean and Andean Association of Rheumatology (Asociación Centroamericana Caribe Andina de Reumatología) - ACCA. It was created in December 1993 with the purpose of disseminating scientific information derived from primary and secondary research and presenting cases coming from the practice of Rheumatology in Latin America. Since its foundation, the Journal has been characterized by its plurality with subjects of all rheumatic and osteomuscular pathologies, in the form of original articles, historical articles, economic evaluations, and articles of reflection and education in Medicine. It covers an extensive area of topics ranging from the broad spectrum of the clinical aspects of rheumatology and related areas in autoimmunity (both in pediatric and adult pathologies), to aspects of basic sciences. It is an academic tool for the different members of the academic and scientific community at their different levels of training, from undergraduate to post-doctoral degrees, managing to integrate all actors inter and trans disciplinarily. It is intended for rheumatologists, general internists, specialists in related areas, and general practitioners in the country and abroad. It has become an important space in the work of all rheumatologists from Central and South America.