Efficacy of levamisole against nematode infestations in dogs

I. Yuskiv, O. L. Tishyn, L. Yuskiv
{"title":"Efficacy of levamisole against nematode infestations in dogs","authors":"I. Yuskiv, O. L. Tishyn, L. Yuskiv","doi":"10.32718/ujvas7-1.14","DOIUrl":null,"url":null,"abstract":"For endoparasitic infestations of dogs, drugs based on levamisole hydrochloride are used. That is why the purpose of the work was to conduct a field study to evaluate the effectiveness of the studied drug “Levamizole O.L.KAR 10 %” and the reference drug “Levamizole-plus 10 %” against endoparasitic infestations of dogs of different breeds, ages, and sexes. According to the results of a parasitological examination of the dogs of the experimental and control groups, endoparasites established spontaneous damage, the causative agents of nematodes of the alimentary canal: species Toxocara canis with an intensity of invasion (II) from 110 to 180 eggs in one gram of feces (EGF) with an average intensity of invasion of 149.0 ± 5.62 EGF, species Toxascaris leonina with an intensity of invasion from 75 to 131 EGF with an average intensity of invasion of 104.4 ± 4.85 EGF and the species Ancylostoma caninum with an intensity of invasion from 48 to 92 EGF with an average intensity of invasion of 69.9 ± 3.71 EGF. Clinically, nematodes of the alimentary canal in dogs were manifested by poor appetite, depressed state, pallor of mucous membranes, mild diarrhea, vomiting, and weight loss observed in some animals. Based on the obtained results, it was established that the studied drug “Levamizol O.L.KAR 10 %” and the reference drug “Levamizol-plus 10 %” when deworming dogs have a pronounced nematodocidal effect against endoparasites of the alimentary canal, which are caused by the following species: Toxocara canis, Toxascaris leonine, Ancylostoma caninum. Thus, the effectiveness of the studied drug “Levamizol O.L.KAR 10 %” for spontaneous toxocariasis infestation in dogs on the seventh day after deworming was 93 %. The reference drug “Levamizol-plus 10 %” was 91 %, and on the 14th day after deworming the animals, the effectiveness of the drugs was 100 %. For spontaneous toxascarosis infestation in dogs, the efficacy of the studied drug “Levamizol O.L.KAR 10 %” on the seventh day after deworming was 95 %. The reference drug “Levamizol-plus 10 %” was 94.4%, and on the 14th day after deworming the animals, the effectiveness of the drugs was 100 %. Helminthological studies have established that for spontaneous hookworm infestation in dogs on the 7th and 14th day after deworming with the study drug and the comparison drug in the recommended doses, the effectiveness of veterinary drugs was 100 %. Field tests showed that the studied drug “Levamizol O.L.KAR 10 %” and the reference drug “Levamizol-plus 10 %” when administered once orally in the recommended doses of the manufacturer, are well tolerated by animals regardless of breed, age, sex, and body weight, not have a toxic effect on the body of animals and are effective against nematodes of the alimentary canal in dogs.","PeriodicalId":231752,"journal":{"name":"Ukrainian Journal of Veterinary and Agricultural Sciences","volume":" 955","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ukrainian Journal of Veterinary and Agricultural Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32718/ujvas7-1.14","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

For endoparasitic infestations of dogs, drugs based on levamisole hydrochloride are used. That is why the purpose of the work was to conduct a field study to evaluate the effectiveness of the studied drug “Levamizole O.L.KAR 10 %” and the reference drug “Levamizole-plus 10 %” against endoparasitic infestations of dogs of different breeds, ages, and sexes. According to the results of a parasitological examination of the dogs of the experimental and control groups, endoparasites established spontaneous damage, the causative agents of nematodes of the alimentary canal: species Toxocara canis with an intensity of invasion (II) from 110 to 180 eggs in one gram of feces (EGF) with an average intensity of invasion of 149.0 ± 5.62 EGF, species Toxascaris leonina with an intensity of invasion from 75 to 131 EGF with an average intensity of invasion of 104.4 ± 4.85 EGF and the species Ancylostoma caninum with an intensity of invasion from 48 to 92 EGF with an average intensity of invasion of 69.9 ± 3.71 EGF. Clinically, nematodes of the alimentary canal in dogs were manifested by poor appetite, depressed state, pallor of mucous membranes, mild diarrhea, vomiting, and weight loss observed in some animals. Based on the obtained results, it was established that the studied drug “Levamizol O.L.KAR 10 %” and the reference drug “Levamizol-plus 10 %” when deworming dogs have a pronounced nematodocidal effect against endoparasites of the alimentary canal, which are caused by the following species: Toxocara canis, Toxascaris leonine, Ancylostoma caninum. Thus, the effectiveness of the studied drug “Levamizol O.L.KAR 10 %” for spontaneous toxocariasis infestation in dogs on the seventh day after deworming was 93 %. The reference drug “Levamizol-plus 10 %” was 91 %, and on the 14th day after deworming the animals, the effectiveness of the drugs was 100 %. For spontaneous toxascarosis infestation in dogs, the efficacy of the studied drug “Levamizol O.L.KAR 10 %” on the seventh day after deworming was 95 %. The reference drug “Levamizol-plus 10 %” was 94.4%, and on the 14th day after deworming the animals, the effectiveness of the drugs was 100 %. Helminthological studies have established that for spontaneous hookworm infestation in dogs on the 7th and 14th day after deworming with the study drug and the comparison drug in the recommended doses, the effectiveness of veterinary drugs was 100 %. Field tests showed that the studied drug “Levamizol O.L.KAR 10 %” and the reference drug “Levamizol-plus 10 %” when administered once orally in the recommended doses of the manufacturer, are well tolerated by animals regardless of breed, age, sex, and body weight, not have a toxic effect on the body of animals and are effective against nematodes of the alimentary canal in dogs.
左旋咪唑对犬线虫感染的疗效
对于狗的内寄生虫病,使用的是以盐酸左旋咪唑为基础的药物。因此,这项工作的目的是进行一项实地研究,以评估所研究的药物 "Levamizole O.L.KAR 10%"和参考药物 "Levamizole-plus 10%"对不同品种、年龄和性别的狗的内寄生虫感染的有效性。根据对实验组和对照组的狗进行寄生虫学检查的结果,内寄生虫自发损害成立,消化道线虫的病原体为:犬弓形虫(Toxocara canis),侵袭强度(II)为每克粪便(EGF)中有 110 至 180 个虫卵,平均侵袭强度为 149.0 ± 5.62 EGF;Toxascaris leonina 的入侵强度为 75 至 131 EGF,平均入侵强度为 104.4 ± 4.85 EGF;Ancylostoma caninum 的入侵强度为 48 至 92 EGF,平均入侵强度为 69.9 ± 3.71 EGF。在临床上,狗的消化道线虫表现为食欲不振、精神萎靡、粘膜苍白、轻度腹泻、呕吐,有些动物还出现体重减轻。根据获得的结果,可以确定所研究的药物 "Levamizol O.L.KAR 10 %"和参考药物 "Levamizol-plus 10 %"在给狗驱虫时对消化道内寄生虫有明显的杀线虫作用,这些寄生虫是由以下种类引起的:犬弓形虫(Toxocara canis)、犬雷氏弓形虫(Toxascaris leonine)、犬锚线虫(Ancylostoma caninum)。因此,所研究的药物 "Levamizol O.L.KAR 10 %"在驱虫后第七天对犬自发性弓形虫感染的有效率为 93%。参考药物 "Levamizol-plus 10 %"的有效率为 91 %,而在驱虫后第 14 天,药物的有效率为 100 %。对于狗的自发性弓形虫感染,研究药物 "Levamizol O.L.KAR 10 %"在驱虫后第七天的有效率为 95 %。参考药物 "Levamizol-plus 10 %"的有效率为 94.4%,而在驱虫后第 14 天,药物的有效率为 100%。蠕虫学研究表明,对于自发性钩虫感染的狗,在用研究药物和对比药物按推荐剂量驱虫后的第 7 天和第 14 天,兽药的有效性为 100%。现场测试表明,研究药物 "Levamizol O.L.KAR 10%"和参照药物 "Levamizol-plus 10%"按照生产商推荐的剂量口服一次后,无论动物的品种、年龄、性别和体重如何,都能很好地耐受,不会对动物的身体产生毒性作用,并且对狗的消化道线虫有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信