Transfusion Support in Hematopoietic Stem Cell Transplantation: A Contemporary Narrative Review

Brian D. Adkins, J. Jacobs, Garrett S. Booth, Bipin N Savani, Laura D. Stephens
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Abstract

Hematopoietic stem cell transplantation (HSCT) is a cornerstone of modern medical practice, and can only be performed safely and effectively with appropriate transfusion medicine support. Patients undergoing HSCT often develop therapy-related cytopenia, necessitating differing blood product requirements in the pre-, peri-, and post-transplant periods. Moreover, ensuring optimal management for patients alloimmunized to human leukocyte antigens (HLA) and/or red blood cell (RBC) antigens, as well as for patients receiving ABO-incompatible transplants, requires close collaboration with transfusion medicine and blood bank professionals. Finally, as updated transfusion guidelines and novel blood product modifications emerge, the options available to the transplant practitioner continue to expand. Herein, we detail contemporary blood transfusion and transfusion medicine practices for patients undergoing HSCT.
造血干细胞移植中的输血支持:当代叙事回顾
造血干细胞移植(HSCT)是现代医疗实践的基石,只有在适当的输血医学支持下才能安全有效地进行。接受造血干细胞移植的患者往往会出现与治疗相关的全血细胞减少症,因此在移植前、移植围期和移植后需要不同的血液制品。此外,要确保对人类白细胞抗原(HLA)和/或红细胞抗原异体免疫的患者以及接受 ABO 不相容移植的患者进行最佳管理,需要输血医学和血库专业人员的密切合作。最后,随着输血指南的更新和新型血液制品的出现,移植医生的选择范围也在不断扩大。在此,我们将详细介绍当代造血干细胞移植患者的输血和输血医学实践。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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