Sevoflurane: an opportunity for stroke treatment

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Gas Research Pub Date : 2024-03-28 DOI:10.4103/2045-9912.386952

Jinhui Xu, Yang Ye, Haitao Shen, Wen Li, Gang Chen

引用次数: 0

Abstract

In developed countries, stroke is the leading cause of death and disability that affects long-term quality of life and its incidence is increasing. The incidence of ischemic stroke is much higher than that of hemorrhagic stroke. Ischemic stroke often leads to very serious neurological sequelae, which severely reduces the patients’ quality of life and becomes a social burden. Therefore, ischemic stroke has received increasing attention. As a new type of anesthetic, sevoflurane has a lower solubility, works faster in the human body, and has less impact on the cardiovascular system than isoflurane. At the same time, studies have shown that preconditioning and postconditioning with sevoflurane have a beneficial effect on stroke. We believe that the role of sevoflurane in stroke may be a key area for future research. Therefore, this review mainly summarizes the relevant mechanisms of sevoflurane preconditioning and postconditioning in stroke in the past 20 years, revealing the bright prospects of sevoflurane in stroke treatment.

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七氟烷：中风治疗的契机

在发达国家，中风是影响长期生活质量的死亡和残疾的主要原因，其发病率正在不断上升。缺血性中风的发病率远高于出血性中风。缺血性脑卒中往往会导致非常严重的神经系统后遗症，严重降低患者的生活质量，成为社会负担。因此，缺血性脑卒中越来越受到重视。作为一种新型麻醉剂，七氟醚的溶解度较低，在人体内起效较快，对心血管系统的影响较异氟醚小。同时，研究表明，使用七氟醚进行预处理和后处理对中风有好处。我们认为，七氟烷在中风中的作用可能是未来研究的一个关键领域。因此，本综述主要总结了近 20 年来七氟醚预处理和后处理在脑卒中中的相关机制，揭示了七氟醚在脑卒中治疗中的广阔前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.10

自引率

13.80%

发文量

期刊介绍： Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.